may be an Alternative to Standard Therapy for Bacteremia and
Endocarditis Caused by
Aureus is a leading cause of bacteremia and endocarditis.
Gentamicin plus penicillin or vancomycin is standard therapy
for S. Aureus bacteremia. Vancomycin is the standard therapy
for blood-stream infections attributable to methicillin-resistant
S. aureus (MRSA). The standard therapy has been associated
with suboptimal outcomes. Vance G. Fowler, Jr., MD, MHS, et
al from Duke University Medical Center set out to establish
whether daptomycin is an effective and safe treatment for S.
aureus bacteremia and endocarditis. The study, published in
the August 17, 2006 issue of The New England Journal of
Medicine found that Daptomycin (6 mg per kilogram daily)
is not inferior to standard therapy for S. aureus bacteremia
and right-sided endocarditis.