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  GENE AND CELL BASED THERAPIES


 Editor: Asher Kimchi, MD
 


Intracoronary Injection of Mononuclear Bone Marrow Cells in Acute Myocardial Infarction Found No Effects on Global Left Ventricular Function
The net loss of cardiomyocytes during myocardial infarction is a key factor in the impairment of cardiac-pump function. The bone marrow contains stem cells that have shown promising results in solid-organ repair and regeneration.  Ketil Lunde M.D. et al from the Rikshospitalet University Hospital in Oslo, Norway designed a randomized, controlled trial to investigate the effects of intracoronary injection of autologous cells from bone marrow (BMC) in the acute phase of myocardial infarction. They investigated whether there was any improvement in left ventricular function after the treatment. The study, published in the September 21, 2006 issue of The New England Journal of Medicine, found no effects of intracoronary injection of autologous mononuclear BMC on global left ventricular function. MOREĽ

Heal thyself: Patients’ bone marrow cells restore failing hearts

Bone marrow cells improve failing heart function

Bone marrow stem cells build new circulation to lungs

Universal bone marrow cell spurs growth of vessels and heart muscle

Growth factor grows stem cells that help heal hearts

Engineered blood vessels prove durable and clot resistant

Tissue-engineered cells transmit electrical signals in animal hearts

Marrow injection gets damaged hearts moving

Muscle cell transplants repair damaged heart tissue

Bone marrow cell transplant treats clogged leg arteries

Cardiovascular Genetics Will Herald New Age of Cardiology

Progenitor cell transplantation enhances functional regeneration in acute MI

 

 

 

 


 

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