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20th World Congress on Heart Disease

 

 

 


20th World Congress on Heart Disease


  IAC MEETINGS

  IAC

International Academy of Cardiology
Annual Scientific Sessions 2015
20th World Congress on Heart Disease



vancouverHyatt Regency Vancouver
Vancouver, BC, Canada
July 25-27, 2015

 

Abstract Deadline:
February 10, 2015


CME Meeting

Publication of Abstracts:
Accepted abstracts will be published in a special online only supplement issue of the journal CARDIOLOGY.

Affiliated with:
American College of Cardiology, California Chapter


The American Society for Preventive Cardiology

Endorsed by:
Heart Valve Society of America


   
         
   
Video from the 16th World Congress on Heart Disease      
 
   
MEETINGS AFFILIATED WITH THE IAC


Controversies and Advances in the Treatment of Cardiovascular Disease: The Fourteenth in the Series
November 20-21, 2014
The Beverly Hills Hotel
Beverly Hills, CA, USA

2014 Arrhythmia Symposium at the Cedars-Sinai Heart Institute
December 5, 2014
Cedars-Sinai Medical Center
Los Angeles, CA, USA




2nd World Congress of Clinical Lipidology
December 5-7, 2014
Cedars-Sinai Medical Center
Vienna, Austria





Tel Aviv 9th International Conference on Acute Cardiac Care
January 18-20, 2015
Tel Aviv, Israel

Advances in Nuclear Cardiology and Cardiac CT: 30th Annual Case Review with the Experts with 101 Evidence-based Cases
January 23-25, 2015
Los Angeles, CA, USA

19th Annual Heart Failure 2015 - Update on Diagnosis and Therapy
April 18, 2015
Los Angeles, CA, USA


To see more information on Meetings Offered in Cooperation with the International Academy of Cardiology, click here.

 


 
 PREVIOUS MEETINGS OF THE IAC
 


boston International Academy of Cardiology
Annual Scientific Sessions 2014
19th World Congress on Heart Disease


Hyatt Regency, Boston, MA, USA
July 25-28, 2014

CME Meeting
Final Program
Download the final program (pdf)


Photos from the 19th World Congress on Heart Disease (click here to see more photos)

Photo Gallery now online. newnew

The scientific program of the 19th World Congress on Heart Disease has been reviewed by the American Medical Association and approved for 23.25 AMA PRA Category 1 Credits™.

Publication of Abstracts:
Accepted abstracts will be published in a special online only supplement issue of the journal CARDIOLOGY.

Affiliated with:
American College of Cardiology, California Chapter

The American Society for Preventive Cardiology

Endorsed by:
Heart Valve Society of America


toronto
International Academy of Cardiology
18th WORLD CONGRESS ON HEART DISEASE
Annual Scientific Sessions 2013

July 26-29, 2013
Hyatt Regency, Vancouver, BC, Canada

CME Meeting
Photo Gallery
Final Program
Download Final Program (pdf)

The scientific program of this Congress has been reviewed by the American Medical Association and approved for a maximum of 25.75 AMA PRA Category 1 Credits™.

Publication of Abstracts:
Accepted abstracts were published in a special online only supplement issue of the journal CARDIOLOGY. Click here to view.


Affiliated with:
American College of Cardiology, California Chapter

The American Society for Preventive Cardiology

Endorsed by:
Heart Valve Society of America


 


Photos from the 18th World Congress on Heart Disease (click here to see more photos)

   toronto 

International Academy of Cardiology
17th WORLD CONGRESS ON HEART DISEASE

Annual Scientific Sessions 2012
July 27-30, 2012
The Fairmont Royal York,
Toronto, ON, Canada

Final Program
Final Program (pdf)

Affiliated with
American College of Cardiology, California Chapter

The American Society for Preventive Cardiology

Endorsed by
Heart Valve Society of America

CME Meeting
*Approved by the American Medical Association for a maximum of 23.75 AMA PRA Category 1 Credits™.

Sending your Article(s) to Monduzzi Editore - Medimond's Proceeding Book

 

Photos from the 17th World Congress on Heart Disease
(Click here to see more photos)

      
International Academy of Cardiology
16th WORLD CONGRESS ON HEART DISEASE

Annual Scientific Sessions 2011
July 23-26, 2011
Hyatt Regency Vancouver, BC, Canada

Final Program
Final Program (pdf)

Program at a Glance (pdf)

Writing Instructions and Sending your Article(s) to Monduzzi Editore - Medimond's Proceeding Book

Affiliated with the American College of Cardiology, California Chapter

CME Meeting

*Approved by the American Medical Association for a maximum of 32.25 AMA PRA Category 1 Credits™.

photos Click here to view photos from the 16th World Congress on Heart Disease


New Horizons in Cardiovascular Disease15th WORLD CONGRESS ON HEART DISEASE
International Academy of Cardiology
Annual Scientific Sessions 2010

July 24-27, 2010
Vancouver, BC, Canada

(click to view index as pdf)

Proceedings Book
ISBN: 978-88-7587-617-3
Available also on CD-ROM


Photos from the 15th World Congress on Heart Disease
(Click here to see more photos)

FINAL PROGRAM
*Approved by the American Medical Association for a maximum of 26.25 AMA PRA Category 1 CME Credits™ 

Endorsed by the American College of Cardiology, California Chapter


Current Advances in Heart Disease14th WORLD CONGRESS ON HEART DISEASE
International Academy of Cardiology
Annual Scientific Sessions 2008

July 26-29, 2008
Toronto, ON, Canada

(click to view index as pdf)

Proceedings Book
ISBN: 978-88-7587-480-3
Available also on CD-ROM

FINAL PROGRAM
*Approved by the American Medical Association for a maximum of 26.25 AMA PRA Category 1 CME Credits™ 

Endorsed by the American College of Cardiology, California Chapter


14th World Congress on Heart Disease

Recent Advances in Cardiovascular Disease 13th WORLD CONGRESS ON
HEART DISEASE

International Academy of Cardiology
Annual Scientific Sessions 2007
July 28 - 31, 2007
Hyatt Regency Vancouver
Vancouver, B.C., Canada

Proceedings Book
ISBN: 978-88-7587-369-1
Available also on CD-ROM


Photos from the 13th World Congress on Heart Disease
(Click here to see more photos)

FINAL PROGRAM & ABSTRACTS
*Approved by the American Medical Association for a maximum of 27 AMA PRA Category 1 CME Credits™  



Advances in Heart Disease INTERNATIONAL ACADEMY OF CARDIOLOGY
12th WORLD CONGRESS ON HEART DISEASE
- NEW TRENDS IN RESEARCH, DIAGNOSIS AND TREATMENT
July 16-19, 2005
Vancouver, BC, Canada


Proceedings Book
ISBN: 88-7587-192-2
Available also on CD-ROM


 Photos from the
12th World Congress on Heart Disease

[Click here to see more photos]

FINAL PROGRAM & ABSTRACTS
* Approved by the American Medical Association for 26.25 AMA PRA Category 1 CME Credits


To see more information on Previous IAC Meetings, click here.

 

PREVIOUS MEETINGS AFFILIATED WITH IAC

18th Annual Heart Failure 2014 - Update on Diagnosis and Therapy
April 5, 2014
Millennium Biltmore Hotel
Los Angeles, CA, USA

New YorkValves in the Heart of the Big Apple VIII: Evaluation & Management of Valvular Heart Disease 2014
May 8-10, 2014
Marriott Marquiz, New York City, NY





cancun
Cardiovascular Disease Prevention 2014: Novel Strategies and Emerging Therapies
February 14-17, 2014
Hilton Molino Stucky
Cancun, Mexico


Venice 3rd International Congress on Cardiac Problems in Pregnancy
February 20-23, 2014
Hilton Molino Stucky
Venice, Italy



Advances in Nuclear Cardiology and Cardiac CT: 29th Annual Case Review with the Experts with 101 Evidence-based Cases
January 24-26, 2014
Cedars-Sinai Medical Center
Los Angeles, CA, USA



Controversies and Advances in the Treatment of Cardiovascular Disease: The Thirteenth in the Series
November 21-22, 2013
The Beverly Hills Hotel
Beverly Hills, CA, USA

 


To see more information on Previous Meetings Under the Auspices of the International Academy of Cardiology, click here.

 

  CARDIOLOGY ONLINE NEWS

Invited Speaker Presentations at the
19th World Congress on Heart Disease (cont'd)

(click on the photo to view the video)


 
19th WORLD CONGRESS ON HEART DISEASE

ATORVASTATIN ATTENUATES ATHEROSCLEROSIS IN THE VALVES AND FEMURS FROM HYPERCHOLESTEROLEMIC LDLR-/- MICE AS=OP Rajamannan
Nalini M. Rajamannan, M.D., Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Atherosclerosis and osteoporosis are the leading causes of morbidity and mortality in the aging population in the Unites States. Evidence indicates that hyperlipidemia plays a paradoxical role in these disease processes. MORE»

 

ATYPICAL AND UNUSUAL CLINICAL PRESENTATIONS OF PATIENTS WITH ISCHEMIC HEART DISEASE Reddy
Hanumanth K. Reddy, M.D., St. Louis University Medical School, St. Louis, Missouri, USA

Ischemic heart disease is the leading cause of death worldwide accounting for 7 million deaths annually. Chest pain is the cardinal symptom in patients with ischemic heart disease (IHD). MORE»

 

TRANSLATION OF HDL FUNCTIONALITY INTO CLINICAL PRACTICE
Rosenson
Robert S. Rosenson, M.D., School of Medicine at Mount Sinai, New York, NY, USA

HDL is conventionally quantified by the cholesterol cargo transported in these protein rich lipoprotein particles. In prospective population studies and clinical trials with low to moderate intensity statins, HDL cholesterol (HDL-C) is biomarker of atherosclerotic cardiovascular disease (ASCVD) risk. MORE»

 

 

DEVICE CLOSURE OF COMPLEX ATRIAL SEPTAL DEFECT IN ADULTS- ISSUES AND SOLUTIONS
Sadiq
Masood Sadiq, M.D., The Children's Hospital/The Institute of Child Health, Lahore. Pakistan

A complex ASD is defined as presence of a large- >20mm (stretched diameter = 26 mm) ASD associated with a deficient (= 4 mm) rim located at the anterior, inferior, or posterior portion of the atrial septum, two separate ASDs within the atrial septum (distant or close to each other); and multi-fenestrated septum, defects associated with a floppy, redundant, and hyper mobile atrial septum (excursion = 10 mm), considered to be aneurysmal, irrespective of their size. MORE»

 

BENEFIT AND RISKS OF ANTIDIABETIC TREATMENT IN PATIENTS WITH CORONARY ARTERY DISEASE AND HEART FAILURE
Saely
Christoph H. Saely, M.D., VIVIT Institute, Academic Teaching Hospital, Feldkirch, Austria

Diabetes mellitus is a paramount risk factor both for coronary artery disease (CAD) and heart failure, and the prevalence of diabetes among patients with CAD or heart failure is high. While better glucose control epidemiologically is associated with a lower incidence of cardiovascular events, lowering blood glucose failed to lower the incidence of macrovascular diabetes complications, i.e. of atherosclerotic cardiovascular disease in multiple trials, in particular among patients with established CAD. MORE»

 

 

PHARMACOLOGICAL MODULATION OF ANGIOTENSIN-II-INDUCED ARTERIAL MONONUCLEAR CELL ADHESION BY NUCLEAR RECEPTORS ACTIVATION
Sanz
Maria J. Sanz, Ph.D., Institute of Health Research INCLIVA, Valencia, Spain

The need of effective strategies to treat and prevent atherosclerosis led us to investigate the effect of combined concentrations of Rosuvastatin (Rosu) and bexarotene (Bex) on angiotensin II (Ang-II)-induced arterial mononuclear cell (MC) recruitment. MORE»

 

 

ROLE OF MINOCYCLINE IN MYOCARDIAL ISCHEMIA-REPERFUSION INJURY: AN OLD DRUG WITH NEW IMPLICATIONS
Scarabelli
Tiziano M. Scarabelli, M.D., Ph.D., St John Hospital & Medical Center/Wayne State University SOM, USA

Minocycline is a semisynthetic second -generation tetracycline with proven safety, which is used in humans for the treatment of acne and urethritis. The drug is also considered for the treatment of severe chronic inflammatory diseases, such as rheumatoid arthritis, as it exerts anti-inflammatory effects that are completely separate and distinct from its antimicrobial action. MORE»

 

HIGH SENSITIVITY CARDIAC TROPONIN – A CARDIOLOGIST'S FRIEND OR FOE?
Schaefer
Saul Schaefer, M.D., University of California, Davis, CA, USA

Cardiac troponin I and T (cTnI and cTnT) are components of the cardiac myocyte myofibrillar apparatus that are released when these cells are injured. Current assays set “normal” at levels that incorporate 99% of the non-diseased population, with usual upper limits in the range of 0.05ug/ml. Troponin elevations are useful in diagnosing acute coronary syndrome (ACS) in conjunction with clinical, electrocardiographic, and imaging data. MORE»

 

 

Invited Speaker Presentations at the 18th World Congress on
Heart Disease (cont'd) (click on the photo to view the video)


 
18th WORLD CONGRESS ON HEART DISEASE

PROTEIN TRANSDUCTION DOMAINS; TARGETED VS. NON-TARGETED TISSUE DELIVERY
ZahidMaliha Zahid, M.D., University of Pittsburgh, Pittsburgh, PA, USA

The ability of certain proteins to cross cell membrane barriers was a chance finding reported over 20 years ago. This ability, also termed protein transduction, is localized to 6-30, basic, cationic peptide motifs, known as protein transduction domains (PTDs). MORE»

OMEGA-3 SUPPLEMENTATION IMPROVES ARTERIAL STIFFNESS AND BIOMARKERS OF CV RISK IN LATINO AND WHITE PATIENTS WITH HYPERTENSION SERVED BY A SAFETY-NET HEALTHCARE SYSTEM
Long Carlin S. Long, M.D., University of Colorado Health Sciences Center and Denver Health Medical Center, Denver, CO, USA

We previously reported on a cross sectional study of Latino and White hypertension patients in a safety-net healthcare system in which Framingham risk factors, markers of inflammation (hsCRP, LPpLA2), arterial stiffness (Pulse wave velocity, augmentation index, and central aortic pressure), and endothelial function (brachial artery flow-mediated dilatation) were measured. MORE»

THE EVOLUTION OF THE PACING SITE: PAST, PRESENT AND FUTURE
Oginosawa
Yasushi Oginosawa, M.D., University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, Japan

As cardiac pacing system for bradyarrhythmias has been developed in clinical practice over half century, the preferential pacing site has been also evolved.[PAST] In the early stage, the object of the pacing was only maintenance of heart rate and pacing lead has been implanted to right atrial appendage and/or right ventricular apex for easiness in terms of implantation and the stability even using conventional passive fixation lead. MORE»

PROTECTIVE EFFECT OF TELMISARTAN AGAINST ENDOTHELIAL DYSFUNCTION AFTER CORONARY DRUG-ELUTING STENT IMPLANTATION IN HYPERTENSIVE PATIENTS
Terashima Mitsuyasu Terashima, M.D., Toyohashi, Japan

Objectives: The aim of this prospective, randomized study was to evaluate the effects of telmisartan on endothelial function after coronary drug-eluting stent (DES) implantation in hypertensive patients, compared to a calcium channel blocker, amlodipine. MORE»

HUMAN ENTEROVIRUS PERSISTENCE: POTENTIAL FOR EXACERBATION OF MYOCARDITIS
ChapmanNora M. Chapman, M.D., University of Nebraska Medical Center, Omaha, NE, USA

Human enteroviruses like the group B coxsackieviruses (CVB) are known to cause human inflammatory cardiomyopathies but until recently, the CVB were thought to be acute infections, rapidly cleared by the host's immune system. We discovered that CVB can persist for weeks to months following either experimental inoculation (in cell cultures or mice) or natural infection (humans) through a mechanism that involves the loss of the 5' terminal genomic sequence. MORE»

NEUTROPHILS IN ACUTE CORONARY ARTERY DISEASE
Filep Janos G. Filep, M.D., Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada

Neutrophil granulocytes are present in atherosclerotic lesions and contribute to inflammatory tissue injury underlying all phases of atherosclerosis from nascent lesions to culmination in acute coronary artery disease (CAD). Acute CAD is characterized by widespread neutrophil accumulation, neutrophil infiltration of culprit lesions and prolonged neutrophil lifespan. MORE»

CRYPTOGENIC STROKE - COULD LONG TERM CARDIAC MONITORING UNCOVER THE CAUSE Gimbel J. Rod Gimbel, M.D., Knoxville, TN, USA

"Cryptogenic Stroke" is defined as an ischemic stroke that is not attributable to a cardioembolic source or large or small vessel disease whose cause remains undetermined after an extensive cardiovascular and hematologic search for the cause. Approximately, 20-25 % of ischemic strokes are "cryptogenic" with some due to unrecognized or undetected atrial fibrillation. MORE»

MACROPHAGES TRANSMIT POTENT PROANGIOGENIC EFFECTS OF oxLDL IN VITRO AND IN VIVO INVOLVING HIF-1a ACTIVATION: A NOVEL ASPECT OF ANGIOGENESIS IN ATHEROSCLEROSISHutterRandolph Hutter, M.D., The Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY, USA

Background: Neovascularization has been linked to the progression and vulnerability of atherosclerotic lesions. Angiogenesis is increased in lipid-rich plaque. Hypoxia-inducible factor alpha (HIF-1a) is a key transcriptional regulator responding to hypoxia and activating genes, which promote angiogenesis, among them vascular endothelial growth factor (VEGF). MORE»

IMPACT OF LIFE STYLE MODIFICATIONS, ANTIANGINALS, ANTIPLATELETS AND LIPID MODIFYING DRUGS AND OF CORONARY ARTERY REVASCULARIZATION ON MORTALITY AND MORBIDITY IN PATIENTS WITH ISCHEMIC HEART DISEASE: TRUTH AND FALSE NOTIONS Thadani
Udho Thadani, M.D., University of Oklahoma HSC and VA Medical Center, Oklahoma City, OK, USA

Stable ischemic heart disease (SIHD) is a new term in vogue; and one must address not only the impact of treatment on symptoms and quality of life but also on mortality and other serious adverse cardiovascular outcomes (SACO) such as myocardial infarction (MI) and stroke. Lifestyle alterations (abstinence of smoking, regular exercise and lipid modifying treatment with statins, reduce the incidence of SACO. MORE»

INTEGRATIVE THERAPY IN CARDIOVASCULAR DISEASE: SAVIOR OR SHAM?
Schaefer
Saul Schaefer, M.D.
, University of California, Davis, CA, USA

While physicians generally treat cardiovascular disease and risk factors with conventional medications such as statins and beta blockers, patients often use complementary or integrative therapy such as fish oil, vitamins, enzymes, and chelation therapy. This $45 billion industry is based on the belief that non-allopathic therapies can lower cardiovascular risk in addition to, or in lieu of, conventional therapy. The NIH Center for Complementary and Alternative Medicine supports therapy "for which there is some high-quality scientific evidence of safety and effectiveness"; MORE»

MEDICAL RISK FACTOR CONTROL IN LARGE TRIALS OF DIABETIC PATIENTS UNDERGOING CORONARY REVASCULARIZATION Farkouh
Michael E. Farkouh, M.D.
, University of Toronto, Toronto, Ontario, Canada

Over the past 2 decades, significant progress has been made in the medical management for patients with coronary artery disease (CAD). Despite guidelines that recommend specific targets for control of risk factors, specifically blood pressure targets in hypertensive patients, low-density lipoprotein (LDL) for those with hyperlipidemia, and glycemic control (HbA1C) in diabetic patients, current large cohort studies demonstrate that a significant proportion of patients do not achieve target risk factor control. MORE»

CHANGES IN HEART ALLOCATION FOR TRANSPLANTATION IN THE US AND WORLDWIDE: OPTIONS FOR A BETTER SOLUTION
Meyer
Dan M. Meyer, M.D.
, University of Texas Southwestern, Med Center at Dallas, Dallas, TX, USA

Objectives: To inform the transplant community of potential modifications in the heart allocation system. Background: Efforts to increase transplantation rates for candidates with highest waiting mortality and offer the greatest survival benefit due to transplantation remains the goal of our current systems. MORE»

SIMULTANEOUS HEART-KIDNEY TRANSPLANTATIONJohnson
Maryl R. Johnson, M.D.
, University of Wisconsin-Madison, Madison, WI, USA

Only around 70 heart-kidney transplants are performed worldwide annually, representing 2-3% of heart transplants and 0.5% of kidney transplants. However, due to the shortage of donor kidneys (in the United States over 95,000 people are waiting for a donor kidney and only 11,000 deceased donor kidney transplants are performed annually), it is important that all candidates receiving a heart-kidney transplant truly need the kidney. MORE»

ULTRAFILTRATION IN THE TREATMENT OF VOLUME OVERLOAD DUE TO HEART FAILUREElkayam
Uri Elkayam, M.D., University of Southern California, Keck School of Medicine, Los Angeles, CA, USA

Volume overload leading to both hemodynamic and symptomatic congestion is the cause for hospitalizations in the majority of cases with heart failure (HF). Ultrafiltration (UF) has been traditionally used for removal of volume in patients with diuretics resistance and those who need removal of a large volume. MORE»

USE OF NMR LDL LIPOPROTEIN PARTICLE ANALYSIS IN CARDIOVASCULAR DISEASE PREVENTION KopeckyStephen L. Kopecky, M.D., Mayo Clinic, Rochester, MN, USA

Low density lipoprotein particle counts, assessed by NMR technology, is available and is a valuable adjunct to the standard lipid profile normally used in lipid management. This technology is most useful in the following 3 settings: MORE»

DEVICE CLOSURE OF ASD- LONG-TERM FOLLOW UP WITH SPECIAL REFERENCE TO COMPLICATIONS Sadiq
Masood Sadiq, M.D.
, The Childrens Hospital, Punjab Institute of Cardiology, Lahore, Pakistan

Device closure of ASD is now standard of treatment for suitable defects. There are however concerns over long-term outcome of device closure with special reference to complications mainly erosions and aortic regurgitation. The long term data is now available. MORE»

CORONARY ARTERY CALCIUM DENSITY AND CARDIOVASCULAR DISEASE EVENTSCriqui
Michael H. Criqui, M.D.
, University of California, San Diego, La Jolla, CA, USA

Background: Coronary artery calcium (CAC) measured by computed tomography (CT) has strong predictive value for incident cardiovascular disease (CVD) events. The standard CAC score is the Agatston, which is weighted upward for greater calcium density. MORE»

IS THERE A PERFECT APPROACH FOR ABLATION PERSISTENT ATRIAL FIBRILLATION? Srivathsan
Komandoor Srivathsan, M.D.
, Mayo Clinic, AZ, USA

Ablation of paroxysmal atrial fibrillation that remains symptomatic despite tolerated antiarrhythmic medication is widely utilized with reasonable success. However, ablative approach in persistent atrial fibrillation remains unclear. Pulmonary vein isolation remains the cornerstone but what additional procedures need to be done to enhance the poor success rate remains inconclusive. MORE»

ANY DEGREE OF MITRAL REGURGITATION FOUND DURING INVASIVE VENTRICULOGRAPHY IS ASSOCIATED WITH ALL CAUSE MORTALITYMovahed
Mohammad R. Movahed, M.D.
, PhD., Arizona, USA

Background: Using a large data base of patients who underwent coronary angiography for clinical reason, we evaluated association between reported degree of mitral regurgitation (MR) with all-cause mortality. MORE»


CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA: THE CLINICIAN'S PERSPECTIVE
LaPage
Martin J. LaPage, M.D.
, Michigan, USA

Catecholaminergic polymorphic polymorphic ventricular tachycardia (CPVT) is a potentially lethal, genetic channelopathy syndrome characterized by ventricular arrhythmias occurring primarily during exercise. Patients typically present with syncope or seizures and initial misdiagnosis is common because baseline cardiac testing is normal. MORE»

MICROBIOTA, SYSTEMIC INFLAMMATION AND CARDIOVASCULAR FUNCTION

Navab
Mohamad Navab, Ph.D.
, David Geffen School of Medicine, University of California Los Angeles, CA, USA

Inflammation contributes to different degrees to most if not all pathological conditions. The GI system including small intestine plays a major role in systemic inflammation and thus cardiovascular well being. MORE»

LEFT ATRIAL APPENDAGE CLOSURE Bertog
Stefan C. Bertog, M.D., CardioVascular Center, Frankfurt, Germany

Atrial fibrillation is a frequent cause of stroke. The mechanism in non-valvular atrial fibrillation is thrombus formation in the left atrium. Ninety percent of left atrial thrombi occur in the left atrial appendage. MORE»

HIGH SENSITIVITY TROPONINS: A STEP FORWARD OR AN UNREQUESTED COMPLICATION?Biasucci
Luigi M. Biasucci, M.D., Catholic University of the Sacred Heart Largo, Rome, Italy

Progressive improvement in the analytical sensitivity of troponin (cTn) assays has led to a more rapid diagnosis of AMI and improved risk stratification in patients with NSTE-ACS, several authors have found that hs-troponin allow a faster and more accurate diagnosis of myocardial infarction (AMI), allowing detection of almost all MI in the first 3 to 6 hours. MORE»


THORACOSCOPIC BIATRIAL MAZE PROCEDURE – A NOVEL MINIMAL-INVASIVE REMEDY WITH PROMISING MIDTERM RESULTS
Khoynezhad
Ali Khoynezhad, M.D., Ph.D.
, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Minimal Access atrial fibrillation has undergone significant progression in last few years. The lesion set has progressed from simple pulmonary vein (PV) isolation to a more comprehensive lesion set, which can be placed epicardially, and more closely replicates the left atrial lesions of the Cox maze III. Less-invasive access has progressed from bilateral mini thoracotomies initially described by Wolf and coworkers, to a totally thorascopic approach initially described by Puskas and coworkers. MORE»

18th WORLD CONGRESS ON HEART DISEASE

USE OF AMBULATORY BLOOD PRESSURE MONITOR (ABPM) FOR GUIDING CARDIAC PATIENTS MANAGEMENT
(click on the photo to view the video)

Charuzi
Yzhar Charuzi, M.D.
, UCLA School of Medicine, CA, USA

24-hours ambulatory blood pressure monitoring has been for years a useful tool to assess variability in blood pressure beyond office checks or self-measurement. We decided to investigate the impact of ABPMs on patient management. The common indication for applying the test was uncertainty of BP fluctuations over a course of 24 hours. MORE»

SCREENING FOR ASYMPTOMATIC CORONARY ARTERY DISEASE: SEEKING VALUE IN A MULTI-MODALITY WORLD
(click on the photo to view the video)

Mahmarian
John J. Mahmarian, M.D., Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, TX, USA

There are multiple potential candidate testing modalities for evaluating patients at risk for coronary artery disease (CAD) which include stress ECG testing; stress echocardiography and myocardial perfusion imaging (MPI); and cardiac computed tomography (CT). Stress echocardiography and MPI are considered inappropriate in low and intermediate risk patients but may have value in patients at high CAD risk. MORE»

CVD IN WOMEN: A FRESH PERSPECTIVE
(click on the photo to view the video)

Kazory
Amir Kazory, M.D.
, University of Florida, Gainesville, FL, USA

While peritoneal dialysis is an established therapy for management of patients with end stage renal disease, it has also been proposed as a means of fluid and sodium extraction in patients with heart failure and volume overload. A number of studies have used this therapeutic modality in various settings and have generally reported positive results. MORE»

THE ROLE OF NITRIC OXIDE/PEROXYNITRITE IMBALANCE IN THE ISCHEMIC HEART
(click on the photo to view the video)

Malinski
Tadeusz Malinski, Ph.D.
, Ohio University, Ohio, USA

Background: The functional endothelial cells are the main source of nitric oxide (NO) in the heart. NO release in the beating heart is stimulated by mechanical forces during systole and diastole. NO release can be also stimulated in the heart by chemical pathways, i.e. epinephrine. MORE»

ANTICOAGULATION AND HEART VALVE DISEASE: IS IT TIME TO RECONSIDER WHO AND HOW?
(click on the photo to view the video)

Borer
Jeffrey S. Borer, M.D., New York, USA

Intra cardiac thrombosis and thromboembolism long have been associated with heart valve diseases (VHD). However, except when atrial fibrillation (AF) coincides with VHD, anticoagulation seldom is considered unless a valve has been replaced, particularly with a mechanical prosthesis. MORE»

BIVENTRICULAR PACING FOR ATRIOVENTRICULAR BLOCK AND SYSTOLIC DYSFUNCTION
(click on the photo to view the video)

Curtis Anne B. Curtis, M.D., Buffalo, New York, USA

Background: Right ventricular pacing restores an adequate heart rate in patients with atrioventricular block, but high percentages of right ventricular apical pacing may promote left ventricular systolic dysfunction. We evaluated whether biventricular pacing might reduce mortality, morbidity, and adverse left ventricular remodeling in such patients. MORE»

REVERSAL OF CARDIAC REMODELING IN HEART FAILURE BY ALPHA-ADRENOCEPTOR BLOCKADE
(click on the photo to view the video)

Dhalla Naranjan S. Dhalla, Ph.D, M.D., MB, University of Manitoba, Winnipeg, Manitoba, Canada

In view of the role of elevated levels of circulating catecholamines, the activation of both alpha-adrenoceptor (AR) and beta-AR is considered to play a critical role in the pathogenesis of heart failure. Previous studies have shown the beneficial effects of beta-AR blockade in the failing heart; however, very little information on the action of alpha-AR blockade is available. MORE»

ALDOSTERONE - A BRIDGE BETWEEN CARDIOVASCULAR AND MOOD DISORDERS?
(click on the photo to view the video)

Jezova Daniela Jezova, M.D., Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovak Republic

Aldosterone is the main mineralocorticoid hormone involved in the control of blood volume. Its effects on water-electrolyte homeostasis have impact on the control of blood pressure and cardiovascular functions. It is well known that the comorbidity of cardiovascular and mental disorder is high, however, aldosterone has not been implicated in the psychopathology so far. MORE»

 

 

Invited Speaker Presentations at the
17th World Congress on Heart Disease (cont'd)

(click on the photo to view the video)

AORTIC DISEASE

THERE IS AN EFFECTIVE MEDICAL TREATMENT FOR THORACIC AORTIC ANEURYSM

(click on the photo to view the video)

Elefteriades
John A. Elefteriades, M.D.,
Yale University School of Medicine, New Haven, CT, USA

Objective: The potential of medical therapy to influence the courses and outcomes of patients with thoracic aortic aneurysms is not known. The aim of this study was to determine whetherstatin intake is associated with improved long-term outcomes in these patients. MORE»

 

CARDIOVASCULAR IMAGING

PROGRESS IN ECHOCARDIOGRAPHY
(click on the photo to view the video)

Nanda
Navin C. Nanda, M.D.,
University of Alabama at Birmingham, Birmingham, AL, USA

Echocardiography has today become the most widely used technique in the noninvasive assessment of cardiac disease entities. It began in the fifties and sixties as A-mode and M-mode echocardiography in which a pencil-thin ultrasound beam was sent to the heart by placing a small transducer on the chest wall and images of very small portions of cardiac structures were obtained at any given time. MORE»

 

CARDIOVASCULAR SURGERY

MANAGEMENT OF EARLY POSTOPERATIVE CORONARY ARTERY BYPASS GRAFT FAILURE

(click on the photo to view the video)

Perrault
Louis P. Perrault, M.D., Ph.D.,
Montreal Heart Institute, Montreal, QC, Canada

Objectives: Perioperative graft failure following coronary artery bypass grafting may result in acute myocardial ischemia. Whether acute percutaneous coronary intervention, emergency reoperation, or conservative intensive care treatment should be used is currently unknown. MORE»

DESIGN OF FUTURE REVASCULARIZATION EVALUATION IN PATIENTS WITH DIABETES MELLITUS: OPTIMAL MANAGEMENT OF MULTIVESSEL DISEASE (FREEDOM TRIAL)
(click on the photo to view the video)

Farkouh
Michael E. Farkouh, M.D.,
University of Toronto, ON, Canada

Indication: Treatment of multivessel coronary artery disease (CAD) in patients with diabetes. Objective: To evaluate whether percutaneous coronary intervention (PCI) with drug-eluting stenting (PCI/DES) is more or less effective than the existing standard of care, coronary artery bypass surgery (CABG). MORE»

 

RISK FACTORS AND PREVENTION

STATINS FOR THE PRIMARY PREVENTION OF CVD IN WOMEN
(click on the photo to view the video)

Mora
Samia Mora, M.D.,
Brigham and Women's Hospital, Boston, MA, USA

The use of statins in patients with manifest cardiovascular disease (CVD) is established, with similar benefit in women and men, but statin use for primary prevention of CVD is controversial particularly for women. We analyzed sex-specific outcomes in JUPITER (Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin) and conducted an updated meta-analysis of statin use for women in primary prevention (20,147 women, >276 CVD events, mean age 63-69 years). MORE»

 

METABOLIC SYNDROME AND DIABETES



  CARDIOLOGY ONLINE NEWS

The Cardiology Online Journal
 Editor: Asher Kimchi, MD

Distinguished Cardiologists and Scientists Honored with 2014 International Academy of Cardiology Awards at the 19th World Congress on Heart Disease, Boston, MA, USA

2014 AwardsDr. Asher Kimchi, Founder and Chairman of the International Academy of Cardiology (IAC) announced the winning recipients of the 2014 IAC Awards at the 19th World Congress on Heart Disease held in Boston, MA, USA. In addition to the IAC awards, the committee also named four faculty to receive the Distinguished Fellowship Award.

Dr. Asher Kimchi, together with Co-Chairmen Dr. Jeffrey S. Borer and Dr. John A. Elefteriades, headed a committee comprised of 225 of the world's leading cardiologists and scientists that reviewed a prestigious list of nominees and voted for their top choice.

The following awards for 2014 were presented at the Opening Ceremony of the International Academy of Cardiology Annual Scientific Sessions 2014, 19th World Congress on Heart Disease, to honor the memory of distinguished colleagues, all former members of the faculty of previous International Academy of Cardiology meetings who made major contributions to Medicine and Cardiology: MORE»

Dr. Nanette K. Wenger to Deliver 8th HJC Swan Memorial Lecture at Opening of International Academy of Cardiology, Annual Scientific Sessions 2014, 19th World Congress on Heart Disease

Asher KimchiAsher Kimchi, M.D.,Founder and Chairman of the International Academy of Cardiology, today announced that Nanette K. Wenger, M.D., Professor of Medicine in the Division of Cardiology at the Emory University School of Medicine, Atlanta, Georgia, USA, will deliver the eighth H.J.C. Swan Memorial Lecture at the Opening Ceremony of the International Academy of Cardiology, Annual Scientific Sessions 2014, 19th World Congress on Heart Disease, that will be held in Boston, MA, USA, from Friday, July 25 through Monday, July 28, 2014.

Nanette WengerDr. Wenger’s presentation, “Gender Disparity in Coronary Heart Disease: Bias, Biology, or Both?” will provide an overview of current understanding of this challenging clinical problem. Cardiovascular disease remains a major cause of mortality for women both in industrialized economies and in developing nations. A stunning improvement has occurred in cardiovascular disease mortality for U.S. women between 2000 and 2010, attributable both to application of evidence-based therapies of established cardiovascular disease and to preventive interventions; these likely derived from research studies of cardiovascular disease in women.
MORE»


 

 

Invited Speaker Presentations at the IAC Annual Scientific Sessions 2014, 19th World Congress on Heart Disease, Boston, MA, USA
(click on the photo to view the video)


 
19th WORLD CONGRESS ON HEART DISEASE

2014 UPDATE ON MANAGEMENT OF HYPERTENSION
Aronow
Wilbert S. Aronow, M.D., Westchester Medical Center/New York Medical College, Valhalla, NY, USA

The American College of Cardiology Foundation/American Heart Association 2011 expert consensus document on hypertension in the elderly recommended the blood pressure (BP) in patients with primary hypertension or in patients at high risk for cardiovascular events such as those with coronary heart disease, stroke, peripheral arterial disease, diabetes, chronic kidney disease, and heart failure be less than 140/90 mm Hg in adults with hypertension younger than 80 years and the systolic BP reduced to 140-145 mm Hg if tolerated in persons with hypertension aged 80 years and older. MORE»
 

PRESENT AND FUTURE OF NUCLEAR CARDIOLOGY AND CARDIAC CT IN CAD: VALUE-BASED IMAGING
Berman
Daniel S. Berman, M.D., Cedars Sinai Medical Center, Los Angeles, CA, USA

The future use SPECT or PET, and cardiac CT will be based on their providing value by improving quality (e.g., reducing events) or decreasing costs. For prevention, coronary calcium scanning can provide value, guiding management more effectively than risk factors or other biomarkers. MORE»

 

 

GI PROTEINS, NATRIURETIC PEPTIDE RECEPTOR C AND REGULATION OF BLOOD PRESSURE
Anand-Srivastava
Madhu B. Anand-Srivastava, Ph.D., University of Montreal, Montreal, Quebec, Canada

C-ANP4-23, a ring deleted analog of atrial natriuretic peptide (ANP) that specifically interacts with natriuretic peptide receptor-C (NPR-C) has been shown to decrease the enhanced expression of Gialpha proteins, implicated in the pathogenesis of hypertension. MORE»

 

MANAGING ANGINA AND RISK VIA IMPROVED ENDOTHELIAL FUNCTION: THE EECP MODEL
Barsness
Gregory Barsness, M.D., Mayo Clinic, Rochester, MN, USA

Enhanced external counterpulsation (EECP) is an outpatient therapy for the treatment of stable ischemic heart disease, angina and heart failure. Although a non-invasive therapy, EECP treatment produces a marked acute hemodynamic effect similar to that produced by the invasive intra-aortic balloon pump. MORE»

 

TICAGRELOR LIMITS MYOCARDIAL INFARCT SIZE- AN ADENOSINE AND COX2 DEPENDENT EFFECT
Birnbaum
Yochai Birnbaum, M.D., Baylor College of Medicine, Texas, USA

In a phase III clinical trial (PLATO) Ticagrelor (TIC) showed better clinical outcomes than Clopidogrel (CLOP) in patients with acute coronary syndromes. In addition to P2Y12 receptor antagonism, TIC prevents cell uptake of adenosine and thus, may augment adenosine effects. MORE»

 

 

AORTIC REGURGITATION: IMPACT OF PREOPERATIVE SYMPTOMS FOR POST-VALVE REPLACEMENT SURVIVAL ON PROGNOSTICATION FROM MYOCARDIAL CONTRACTILITY
Borer
Jeffrey S. Borer, M.D., State University of New York Downstate Medical Center, New York, NY, USA

Both preoperative symptoms and severe preoperative myocardial contractility deficit predict survival among patients (pts) undergoing aortic valve replacement (AVR) for aortic regurgitation (AR). The interactive effects of these predictors are unknown. MORE»

SERENDIPITY IN MEDICINE; DOES CHANCE TRULY FAVOR THE PREPARED MIND?
Biederman
Robert W.W. Biederman, M.D. , Carnegie Mellon University, Allegheny General Hospital, Pittsburgh, PA, USA

Serendipity means a "fortuitous happenstance" or "pleasant surprise". It was first coined by Horace Walpole in 1754. In a letter he wrote to a friend Walpole explained an unexpected discovery he had made by reference to a Persian fairy tale, The Three Princes of Serendip. MORE»


SUCCESSFUL EVAR PROGRAM FOR AAA IN A RURAL HOSPITAL
Butman
Samuel M. Butman, M.D., Verde Valley Medical Center, Cottonwood, AZ, USA

Endovascular aortic aneurysm repair (EVAR) is now widely accepted as the preferred method of mitigating the risk of rupture in patients with documented abdominal aneurysms. Beginning in higher volume centers, the procedure is now performed in smaller community hospitals. MORE»

PREDICTION OF ARRHYTHMIC EVENTS WITH POSITRON EMISSION TOMOGRAPHY
Cain
Michael E. Cain, M.D., University at Buffalo, Buffalo, NY, USA

Between 184,000 and 462,000 Americans die suddenly each year. Fifty to seventy percent of these deaths are due to ventricular tachycardia/ fibrillation (VT/VF). We tested whether hibernating myocardium or myocardial sympathetic denervation identifies patients at high-risk for developing VT/VF independently of EF. MORE»


THE ROLE OF PROGENITOR CELLS IN ATHEROSCLEROSIS
Caplice
Noel M. Caplice, M.D., Ph.D., University College Cork, Cork. Ireland

We previously showed that circulating cells with smooth muscle outgrowth potential exist in the peripheral circulation and that bone marrow derived precursor cells contribute to smooth muscle cells within murine and human atherosclerotic plaque. More recently we have defined a myeloid subpopulation of cells that undergo smooth muscle cell differentiation following signalling through the CX3CR1 chemokine receptor. MORE»

LOW GRADIENT SEVERE AORTIC STENOSIS: DIAGNOSIS AND MANAGEMENT
Chaliki
Hari P. Chaliki, M.D., Mayo Clinic, Arizona, USA

According to the most recent American College of Cardiology/American Heart Association guidelines, peak velocity greater than 4 m/sec, a mean gradient of more than 40 mmHg and a valve area of less than 1.0 cm2 is considered severe aortic stenosis (AS). Aortic valve surgery should be done promptly in symptomatic patients or patients with reduced left ventricular ejection fraction (EF) with severe AS because of a dismal prognosis without operation. MORE»


DUAL UTILIZATION OF EXERCISE ECHOCARDIOGRAMS AND MYOCARDIAL PERFUSION IN ASSESSING ISCHEMIA IN A CARDIOLOGY PRACTICE
Charuzi
Yzhar Charuzi, M.D., Cedars Sinai Heart Institute, Los Angeles, CA, USA

In patients with suspected ischemia, the data derived from one type of imaging test may be insufficient to assess its significance. In 62 patients, two imaging techniques were utilized to assess the extent of ischemia and help determine clinical management. MORE»

CLINICAL EFFECTIVENESS OF CRT AND ICD THERAPY IN PATIENTS WITH HEART FAILURE BY RACE AND GENDER: FINDINGS FROM IMPROVE HF
Curtis
Anne B. Curtis, M.D., University at Buffalo, Buffalo, NY, USA

Background: Clinical trials have demonstrated benefit for cardiac resynchronization therapy (CRT) and implantable cardioverter defibrillator (ICD) therapies in patients with heart failure (HF) and reduced ejection fraction (EF), yet questions have been raised with regard to the benefit of device therapy for women and minorities. MORE»


DUAL AT1 RECEPTOR/NEPRILYSIN INHIBITION ('ARNI') IN HYPERTENSION: AN IMPROVEMENT VERSUS AT1 RECEPTOR BLOCKADE?
Danser
A.H. Jan Danser, M.D., Erasmus Medical Center, Rotterdam, The Netherlands

Neprilysin inhibitors (NEPi) prevent natriuretic peptide breakdown, thereby promoting vasodilation and natriuresis. On the other hand, they increase angiotensin and endothelin-1 (ET-1). The combined NEP/ACE inhibitor omapatrilat displayed potent effects in hypertension and heart failure, but these were accompanied by the occurrence of angioedema due to bradykinin accumulation. MORE»

POTENTIAL THERAPY FOR THE PREVENTION OF SUDDEN CARDIAC DEATH
Dhalla
Naranjan S. Dhalla, Ph.D., M.D.(Hon), St. Boniface General Hospital Research Centre, University of Mantioba, Winnipeg, Canada

Objectives: Although sudden cardiac death is a leading cause of mortality, the mechanisms for its pathogenesis as well as therapy for prevention are poorly understood. Background: Since overactivation of sympathetic nervous system is invariably seen in subjects with high risk for sudden cardiac death, elevated levels of circulating catecholamine levels are considered to result in lethal ventricular arrhythmias and subsequent sudden cardiac death. MORE»


MITOCHONDRIAL DYSFUNCTION AND ARRHYTHMIC RISK: POSSIBLE NEW THERAPIES FOR SUDDEN DEATH
Dudley
Samuel C. Dudley, M.D., Ph.D., Brown University and Lifespan Cardiovascular Institute, Providence, RI, USA

Mitochondria are essential to providing ATP thereby satisfying the energy demand of the incessant electrical activity and contractile action of cardiac muscle. Emerging evidence indicates that mitochondrial dysfunction can adversely affect cardiac electrical functioning by impairing the intracellular ion homeostasis and membrane excitability through reduced ATP production and excessive reactive oxidative species (ROS) generation, resulting in increased propensity to cardiac arrhythmias. MORE»

FUNCTIONAL AND ANATOMICAL CARDIAC IMAGING IN PATIENTS WITH CORONARY ARTERY STENTS
Elhendy
Abdou Elhendy, M.D., Ph.D., Marshfield Clinic, Marshfield, WI, USA

Coronary artery stenting has been shown to improve myocardial function, and ameliorate angina. The number of complex interventional procedures has recently increased due to technical advances. However, myocardial perfusion may be compromised after coronary stenting by acute thrombosis or the development of fibrointimal hyperplasia leading to decline in left ventricular function and increased risk of myocardial infarction. MORE»


REGRESSION OF HYPERTROPHY (AND FIBROSIS?) IN HYPERTROPHIC CARDIOMYOPATHY
Fifer
Michael A. Fifer, M.D., Massachusetts General Hospital, Boston, MA, USA

Left ventricular (LV) hypertrophy and fibrosis are important determinants of morbidity and mortality in hypertrophic cardiomyopathy (HCM). Regression of hypertrophy remote from the interventricular septum is observed after septal reduction therapy with myectomy or alcohol ablation. MORE»

TOLL-LIKE RECEPTOR 9 REGULATION OF COAGULATION IN ACUTE CORONARY ARTERY DISEASE
Filep
Janos G. Filep, M.D., Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada

Bacteriemia has recently been reported to be associated with increased risk of acute coronary artery disease and stroke. Bacterial DNA containing unmethyled CpG dinucleotide motifs is potent inducer of immune responses predominantly through Toll-like receptor 9 (TLR9). MORE»


A CASE OF ORTHOSTATIC HYPOTENSION AND RECENT ADVANCES
Fung
Gordon L. Fung, M.D., M.P.H., Ph.D., UCSF Medical Center at Mt. Zion, San Francisco, CA, USA

JM is a 78 year old man who had a history of hypertension and developed an ascending aortic aneurysm while under treatment. He presented to the hospital for elective prostate operation and was seen by Cardiology for evaluation of atypical chest pain. The patient gave a history of recurrent syncope over the past 6 years with syncope every 1-2 years. MORE»

MOLECULAR DRIVERS OF VASCULAR REMODELING
Galis
Zorina Galis, Ph.D., Division of Cardiovascular Sciences, NIH, Bethesda, MD, USA

During their natural history, blood vessels undergo enduring, and sometimes irreversible structural changes in size and composition, a process commonly referred to as vascular remodeling. Many of these changes are initiated as a physiological response allowing adaptation and repair of the vessel wall, however inappropriate remodeling underlies the pathogenesis of major cardiovascular conditions, such as atherosclerosis, hypertension, or aneurysmal disease. MORE»


MANAGEMENT OF STABLE ISCHEMIC HEART DISEASE: OVERVIEW OF RECENT GUIDELINES
Gardin
Julius M. Gardin, M.D., Hackensack University Medical Center, NJ, USA

Management guidelines regarding diagnosis and treatment of stable ischemic heart disease (SIHD) have evolved with time. In 2012, the ACCF/AHA/ACP SIHD Guidelines (Fihn, Gardin, et al.) emphasized important concepts, e.g., the following: (1) Most SIHD patients should have a trial of guideline-directed medical therapy (GDMT), including risk factor modification, before considering revascularization to improve symptoms. MORE»

TRANSLATING T3 TREATMENT OF HEART FAILURE FROM BENCH TO BEDSIDE: FINALLY, A SAFE TREATMENT/MONITORING PROTOCOL THAT SHOULD WORK!
Gerdes
A. Martin Gerdes, Ph.D., New York Institute of Technology, Old Westbury, NY, USA

The idea of treating heart failure with thyroid hormones (THs) is not new. Unfortunately, cardiovascular clinical studies mostly using TH analogs at excessive doses demonstrated an increased incidence of arrhythmias and have largely deterred further studies. At the heart of the problem, no one has clearly demonstrated potential benefits using a therapeutic TH treatment/monitoring protocol that can be safely translated to humans. MORE»


CAN WE PREVENT HEART FAILURE READMISSIONS?
Heidenreich
Paul A. Heidenreich, M.D., Stanford University, Palo Alto, CA, USA

Readmissions are common following an admission for heart failure occurring in 20-30% of patients within 30 days of discharge. Many payers including U.S. Medicare have estimated that a large fraction of these readmissions are preventable (up to 75%). MORE»

GUIDING PRINCIPLES IN STATIN UTILIZATION: EMERGING CLINICAL AND PUBLIC HEALTH CHALLENGES
Hennekens
Charles H. Hennekens, M.D., Dr.P.H., Florida Atlantic University, Boca Raton, FL, USA

The current totality of evidence on statins in treatment and prevention of cardiovascular disease (CVD) includes 170,000 secondary prevention and high risk primary prevention patients. Those assigned at random to a statin had statistically significant and clinically important reductions in myocardial infarction of 30%, stroke of 15%, the need for stents and coronary artery bypass grafts of 25% and coronary death of 22%. MORE»


SLEEP-TIME BLOOD PRESSURE AS A THERAPEUTIC TARGET FOR CARDIOVASCULAR RISK REDUCTION
Hermida
Ramon C. Hermida, Ph.D., Campus Universitario, Vigo, Pontevedra, Spain

Diagnosis of hypertension and clinical decisions regarding its treatment are typically based upon clinic blood pressure (BP) measurements, occasionally supplemented by wake-time patient self-assessment. Yet, correlation between BP level and target organ damage, cardiovascular disease (CVD) risk, and long-term prognosis is greater for ambulatory BP monitoring (ABPM) than daytime in-clinic measurements. MORE»

COLCHICINE AND NEW MANAGEMENT STRATEGIES FOR ACUTE AND RECURRENT PERICARDITIS
Imazio
Massimo Imazio, M.D., Maria Vittoria Hospital, Torino, Italy

Bacteriemia has recently been reported to be associated with increased risk of acute coronary artery disease and stroke. Bacterial DNA containing unmethyled CpG dinucleotide motifs is potent inducer of immune responses predominantly through Toll-like receptor 9 (TLR9). MORE»


A CASE OF ORTHOSTATIC HYPOTENSION AND RECENT ADVANCES
Jezova
Daniela Jezova, M.D., Slovak Academy of Sciences, Bratislava, Slovakia

In comparison to coronary heart disease, the pathogenic mechanisms in stroke are very heterogeneous and reliable biomarkers to predict stroke severity and outcome are not available yet. The activation of neuroendocrine functions, particularly those involved in the stress response, represent important aspects of stroke pathophysiology. MORE»

COLCHICINE AND NEW MANAGEMENT STRATEGIES FOR ACUTE AND RECURRENT PERICARDITIS
Jo
Hanjoong Jo, Ph.D., Dept. of Biomedical Engineering, Emory University, Atlanta, GA, USA

Atherosclerosis is the major underlying cause of myocardial infarction and stroke and preferentially occurs in arterial regions exposed to disturbed flow (d-flow) by mechanisms involving broad changes in gene expression. We have shown that D-flow rapidly induces atherosclerosis in vivo using a mouse partial carotid ligation model. MORE»


FRACTIONAL FLOW RESERVE (FFR) AT 2014- WHERE ARE WE AND WHERE IS IT GOING
Kaluski
Edo Kaluski, M.D., University Hospital, Newark, NJ, USA

New society guidelines support now the use of FFR over to assess intermediate stable native coronary lesions (now defined as 50-90% diameter stenosis when stress imaging is contraindicated, non-diagnostic, discordant or unavailable. MORE»

CARDIORENAL SYNDROME: NOT AS STRAIGHT FORWARD AS WE USED TO THINK
Kazory
Amir Kazory, M.D., University of Florida, Gainesville, FL, USA

Simultaneous dysfunction of the heart and the kidney represents a distinct spectrum of disease states composed of complex clinical scenarios with potentially adverse outcomes. Worsening renal function (WRF) in the setting of acute decompensated heart failure (ADHF) is one such clinical setup with not yet well-characterized underlying mechanisms. MORE»


THE EFFECT OF BENDAVIA ON ISCHEMIA/REPERFUSION INJURY, LEFT VENTRICULAR REMODELING AND DYSFUNCTION
Kloner
Robert A. Kloner, M.D., Ph.D., Good Samaritan Hospital/USC, Los Angeles, CA, USA

Background and Objectives: Bendavia is a small water soluble molecule that freely crosses cell membranes and localizes to the inner mitochondrial membrane where it associates with cardiolipin and reduces intracellular reactive oxygen species (ROS) production. Our objective was to determine Bendavia’s effect on myocardial infarction. MORE»

INNATE IMMUNITY AND HEART DISEASE
Knowlton
Anne A. Knowlton, M.D., University of California, Davis, CA, USA

The innate immune system is a primitive, rapid immune response that responds to detected threats by producing a rapid inflammatory response. A series of pattern recognition receptors (PRR) recognizes molecular patterns (pathogen associated molecular patterns or PAMPs) that are common to microbes and to danger signals (damage-associated molecular patterns or DAMPs) from injured cells. MORE»


NON PHARMACOLOGICAL AND CATHETER BASED THERAPY OF DIFFICULT TO TREAT (D2T) HYPERTENSION
Koshy
Santhosh K. Koshy, M.D., UT Health Sciences Center, Memphis, TN, USA

Resistant or difficult to treat hypertension is not uncommon and is a nightmare for both primary care physicians and specialists. It is defined as an uncontrolled hypertension with blood pressure consistently above 140/90mmHg despite adequate regimen with four or more anti-hypertensives, preferably with one that includes a diuretic. MORE»

PCI VERSUS CABG IN MULTIPLE VESSEL CAD
Kumar
Adarsh Kumar, M.D., Govt Medical College/GND Hospital, Amritsar, India

CAD is number one killer in the world. CABG and PCI are both safe and established invasive treatment modalities for CAD. However conflicting information exists when comparing their long term efficacy in multiple vessel disease (MVD). MORE»


METABOLIC SYNDROME CRITERIA: CAUSE VERSUS EFFECT OF CARDIOMETABOLIC DISEASE
Levine
T. Barry Levine, M.D., Drexel University College of Medicine, Philadelphia, PA, USA

Although metabolic syndrome (MetSyn)-criteria provide a convenient tool to recognize individuals at increased cardiometabolic disease-risk, they appear haphazard, mixing descriptors of body-phenotype with lab-tests and a vascular condition. Are MetSyn-criteria causes or effects? MORE»

MITOCHONDRIAL DYSFUNCTION AND DIABETIC HEART DISEASE
Liang
Qiangrong Liang, M.D., Ph.D., New York Institute of Technology, Old Westbury, NY, USA

Most diabetic patients die from heart disease or stroke, highlighting the importance of understanding and treating cardiovascular complications of diabetes. A large body of evidence indicates that mitochondrial dysfunction and increased generation of reactive oxygen species (ROS) are critical to diabetic heart damage. MORE»


CARBON NANOTUBES SCAFFOLDS AS A NEW BASIS FOR CARDIAC TISSUE ENGINEERING
Long
Carlin S. Long, M.D., University of Colorado Health Sciences Center, Denver Health Medical Center, Denver, CO, USA

In our previously published work we reported that MWCNTs used as growth supports for culturing neonatal rat ventricular myocytes (NRVM) increase myocyte proliferation and induce a more negative resting potential, suggesting that carbon nanotubes promote cardiomyocyte maturation. However, the mechanistic link between the enhanced cardiomyocyte proliferation and maturation and carbon nanotubes interaction was unknown. MORE»

USE OF FRACTION FLOW RESERVE TO PREDICT CHANGES OVER TIME IN MANAGEMENT OF SUPERFICIAL FEMORAL ARTERY
Lotfi
Amir S. Lotfi, M.D., Tufts University School of Medicine, Baystate Medical Center, Springfield, MA, USA

Background: Peripheral arterial disease (PAD) is a condition characterized by progressive narrowing of the arteries in the peripheral vascular bed which affect patient quality of life. The purposes of this study were to 1) establish the feasibility of performing peripheral FFR (pFFR) in the peripheral vascular circulation, 2) correlate post intervention pFFR with future restenosis, and 3) demonstrate an association between pFFR and peak systolic velocity measured by duplex ultrasound. MORE»


TRIGGERS OF ACUTE CARDIOVASCULAR EVENTS: CLINICAL IMPLICATIONS
Madjid
Mohammad Madjid, M.D., Texas Heart Institute, Houston, TX, USA

Atherosclerotic cardiovascular events result from two separate phases of mechanistic processes. Whereas lipid accumulation and chronic latent inflammation lead to development of atherosclerotic plaques over a period of years, certain internal or external factors can “trigger” the transformation of stable plaques into unstable plaques within hours to weeks, causing an acute coronary syndrome (ACS). MORE»

STRESS-ONLY IMAGING; A NEW PARADIGM FOR PERFORMING STRESS MYOCARDIAL PERFUSION IMAGING
Mahmarian
John J. Mahmarian, M.D., Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas, USA

Background: There have been continued efforts over the past several years to utilize a patient-centered imaging approach when performing stress myocardial perfusion imaging (MPI). One such approach has been to choose a single day stress/rest imaging strategy so that if the stress study is normal, rest imaging is unnecessary. MORE»


PRECISION MEDICINE FOR TODAY AND TOMORROW: TARGETING MOLECULAR PATHWAYS FOR VASCULAR DISEASE
Maiese
Kenneth Maiese, M.D., University of Medicine & Dentistry of New Jersey, Newark, NJ, USA

Molecular targeting is becoming increasing recognized as a necessary means for drug development and the successful treatment of an individual’s disease onset and progression. Although multiple pathways can be responsible for cardiac or vascular disorders in patients, kinase pathways in the vascular system that involve phosphoinositide 3-kinase (PI 3-K), protein kinase B (Akt), and the mammalian target of rapamycin (mTOR) offer especially exciting prospects for developing strategies for disease in the cardiovascular system. MORE»

WOMEN AND HEART DISEASE: UPDATE ON PREVENTION
Malik
Shaista Malik, M.D., Ph.D., M.P.H., University of California, Irvine, CA, USA

Cardiovascular disease remains the leading killer of both men and women in the United States. However, compared to men, women have higher rates of morbidity and mortality secondary to cardiovascular disease. MORE»


THE PIVOTAL ROLE OF L-ARGININE IN THE ISCHEMIC HEART PRECONDITIONING - A NANOMEDICAL APPROACH
Malinski
Tadeusz Malinski, Ph.D., Dr.h.c.m., Ohio University, Athens, OH, USA

Ischemic preconditioning with a short coronary artery occlusion has been shown to protect the heart against a subsequent myocardial infarction. Although several endogenous molecules have been implicated in the heart adaptation to an ischemic event, its mechanism is not well understood. A nanomedical approach was used to study, in vivo and ex vivo, the concentration changes of small molecules in the heart during preconditioning. MORE»

TEMPORAL VARIATION IN ACUTE AORTIC DISEASES: ONLY A RANDOM PHENOMENON?
Manfredini
Roberto Manfredini, M.D., University of Ferrara, Italy

Chronobiology is a branch of biomedical sciences devoted to the study of biological rhythms, that according to cycle length, are classified into: circadian (period of around 24 hours), ultradian (less than 24 hours), and infradian (more than 24 hours, e.g., days, weeks, months), and their interactions with bodily functions. MORE»


DEMOGRAPHIC CHANGES IN CONGENITAL HEART DISEASE IN THE XXI CENTURY: IMPACT IN MANAGEMENT AND OUTCOMES
Marelli
A.J. Marelli, M.D., M.P.H., Mc Gill University Health Centre, Montreal, QC, Canada

The field of complex congenital heart disease (CHD) has evolved greatly, allowing for more patients to survive into adulthood. Emerging is a new era of changing demographics that must be matched with services and infrastructures commensurate with its growth. MORE»

 

Invited Speaker Presentations at the IAC Annual Scientific Sessions 2013, 18th World Congress on Heart Disease, Vancouver, BC, Canada
(click on the photo to view the video)


 
18th WORLD CONGRESS ON HEART DISEASE

INFLAMMATION - THE NEW TARGET FOR PREVENTION OF CORONARY ARTERY DISEASE
Roberts Robert Roberts, M.D., University of Ottawa Heart Institute, ON, Canada

New Technology that evolved in 2005 made it possible to genotype the whole human genome sequence utilizing a million DNA markers in the form of single nucleotide polymorphisms (SNPs). This led to the first genome-wide association study (GWAS) in pursuit of the genes for coronary artery disease (CAD). MORE» 

PRACTICAL GENETICS OF THORACIC AORTIC ANEURYSM
Elefteriades
John A. Elefteriades, M.D.
, Aortic Institute at Yale-New Haven, CT, USA

The discovery of the genetics of thoracic aortic aneurysm dates back to observations by Hippocrates in 400 BC. The contributions of Marfan, Ehler, and Danlos are well-appreciated. Another germinal advance was the recognition in 1981 by M. David Tilson at Yale that abdominal aortic aneurysm runs in families. MORE»

SEX DIFFERENCES IN CARDIOVASCULAR DISEASE
Regitz_Zagrosek Vera Regitz-Zagrosek, M.D., Center for Cardiovascular Research, Berlin, Germany

Sex differences affect the presentation, treatment results, and outcomes of cardiovascular diseases. Men suffer at younger ages than women from coronary artery disease and hypertension and more commonly develop systolic heart failure or aortic aneurysms. Women are more frequently affected by heart failure with preserved ejection fraction, long QT-syndromes and Tako-tsubo cardiomyopathy. MORE»  

CPT1b DEFICIENCY IS BAD FOR THE HYPERTROPHIED HEART
Yang
Qinglin Yang, M.D.
, University of Alabama at Birmingham, AL, USA

Objective: To investigate the effect of Carnitine palmitoyltransferase 1b (CPT1b) deficiency on pressure overload-induced cardiac hypertrophy. Background: CPT1 is a rate-limiting step of mitochondrial ß-oxidation by controlling the mitochondrial uptake of long-chain acyl-CoAs. MORE»

IS DIABETES REALLY A CORONARY HEART DISEASE RISK EQUIVALENT?
Wong Nathan D. Wong, Ph.D., University of California, Irvine, CA, USA

Type 2 diabetes (T2DM) is associated with substantial increases in morbidity and mortality from coronary heart disease (CHD) and has been considered a CHD risk equivalent by the US National Cholesterol Education Program. The East-West Study originally showed persons with diabetes but no prior myocardial infarction had a similar risk of future CHD events as those with a prior myocardial infarction and no diabetes. MORE»

INTERACTION OF GENE AND SALT DIETS ON CARDIAC ANGIOTENSIN II, ALDOSTERONE, AND CYTOKINES IN HYPERTROPHIED HEART
Pandey
Kailash N. Pandey, Ph.D.
, Tulane University School of Medicine, LA, USA

The objective of the present study was to elucidate the interactive roles of guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) gene (Npr1) and salt diets on cardiac angiotensin II (ANG II), aldosterone (ALDO), and pro-inflammatory cytokines in hypertrophied hearts. Npr1 genotypes included gene-disrupted heterozygous (+/-; 1-copy), wild-type (+/+; 2-copy), gene-duplicated heterozygous (++/+; 3-copy), and gene-duplicated homozygous (++/++; 4-copy) mice. Animals were fed with low, normal, and high salt-diets. MORE»

PERSONALIZED MEDICINE IN DILATED CARDIOMYOPATHY
Mestroni Luisa Mestroni, M.D., University of Colorado, CO, USA

Clinical genetic testing is becoming more mainstream in inherited disorders, such as cardiomyopathies. At the same time, newer DNA sequencing technology can now complete the sequencing of an entire human genome several times over in a matter of days, in an efficient and cost effective manner. However, the extent of remarkable genetic variation is increasingly being appreciated and this undoubtedly adds new challenges to the difficulty of distinguishing true pathogenetic variants from benign variants in diagnostic genetics and in the research setting. MORE»

MITOCHONDRIAL FISSION AND FUSION IN HEART FAILURE
Knowlton
Anne A. Knowlton, M.D.
, University of California, Davis, CA, USA

Mitochondrial fusion and fission are essential processes for preservation of normal mitochondrial function. OPA1, a mitochondrial fusion protein, is decreased in both human and rat failing hearts. A number of inherited neuropathies are associated with mutation of fission/fusion proteins, including Charcot-Marie-Tooth (CMT) disease. MORE»

NEW INSIGHT INTO TREATMENT OF AORTIC STENOSIS: LIGHT AT THE END OF THE TUNNEL
Heistad Donald D. Heistad, M.D., University of Iowa, IA, USA

No medical therapy for fibro-calcific aortic valve stenosis (FCAVS) is effective. We have developed experimental models of severe FCAVS in mice, and are using these models to examine interventions that may be useful in slowing the development or progression of FCAVS. MORE»

CAROTID ULTRASOUND EVALUATION OF SUBCLINICAL ATHEROSCLEROSIS IN 2013: PROGRESS AND PITFALLSGardin Julius M. Gardin, M.D., Hackensack University Medical Center, NJ, USA

Carotid artery ultrasound intima-medial thickness (IMT) measurements are reported to add predictive value to traditional risk factors for predicting myocardial infarction and stroke. Recently, we reported that the Lifetime Risk algorithm was superior to both 10-year and 30-year Framingham Risk Score (FRS) algorithms in assigning subjects with carotid or femoral plaques to the high-risk FRS category for women aged 20-to-60 years and for men aged =50 years. MORE»

PREVENTION OF REPERFUSION INJURY IN PATIENTS WITH ST ELEVATION MYOCARDIAL INFARCTION: THE CGMP PATHWAY
Garcia-Dorado David Garcia-Dorado, M.D., Ph.D., Vall d'Hebron University Hospital, Barcelona, Spain

Despite standard-of-the-art reperfusión therapy, most patients with ST elevation myocardial infarction (STEMI) present significant myocardial necrosis, and many of them experience adverse left ventricular remodeling and adverse outcomes. Coadjuvant therapies able to limit necrosis in these patients by reducing reperfusion injury are thus of great potential clinical interest. MORE»

IMPACT OF DENERVATED MYOCARDIUM ON IMPROVING RISK STRATIFICATION FOR SUDDEN CARDIAC DEATH
Cain
Michael E. Cain, M.D.
, University at Buffalo, NY, USA

The annual incidence of sudden cardiac death in the United States is between 184,000 and 462,000, with estimates that 50% to 70% of the deaths are due to VT or VF. Availability of therapies shown to reduce death in various at-risk groups, including beta-blockers, ACE- inhibitors, statins, aldosterone blockers, and the implantable cardiac defibrillator (ICD), underscore the need to accurately identify patients who will develop VT/VF and exclude those who will not. MORE»

DIHYDROFOLATE REDUCTASE IN CARDIOVASCULAR PATHOPHYSIOLOGY
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Garcia-Dorado Linda Cai, M.D., Ph.D., UCLA David Geffen School of Medicine, CA, USA

It has become clear during the past decade that endothelial nitric oxide synthase (eNOS) can transform into a superoxide-generating/pro-oxidant enzyme, when its essential cofactor tetrahydrobiopterin (H4B) becomes deficient. This phenomenon is now referred to as eNOS uncoupling. MORE» 

NOVEL USES OF CARDIAC MRI FOR NON-ISCHEMIC HEART DISEASE
Biederman Robert W. W. Biederman, M.D., Carnegie Mellon University, PA, USA

While the evaluation of ischemic cardiomyopathy (ICMX) has been well defined via Cardiovascular MRI (CMR), less is understood how the application of similar approaches can be incorporated for the identification non-ischemic cardiomyopathy (NICMX), often defining many obscure diagnoses. The utility for accurate, rapid, inexpensive and robust technique not requiring biopsy confirmation has particular value in the armamentarium of informed clinicians. MORE»

ENHANCING GLUCOSE OXIDATION AS AN APPROACH TO TREAT 403 HEART FAILURE
Lopaschuk
Gary Lopaschuk, Ph.D., University of Alberta, Edmonton, AB, Canada

Alterations in cardiac energy metabolism contribute to the impaired heart function observed in heart failure patients. The failing heart is both energy compromised, as well as inefficient at producing energy. MORE»

THE HIGH CORONARY DISEASE RISK OF SOUTH ASIAN AMERICANS
Klatsky
Arthur L. Klatsky, M.D., Kaiser Permanente Medical Center, Oakland, CA, USA

Objective and Background: Prevalence data and case-control studies suggest high coronary artery disease (CAD) risk in South Asians (SA) but prospective studies remain sparse. We performed a comprehensive prospective analysis in a large population. MORE»

18th WORLD CONGRESS ON HEART DISEASE


LOW INCOME IS AN INDEPENDENT PREDICTOR OF IN-HOSPITAL MORTALITY AMONG HEART TRANSPLANT RECIPIENTS: A NATIONWIDE INPATIENT SAMPLE STUDY
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Aronow
Wilbert S. Aronow, M.D.
, New York Medical College, NY, U.S.A.

Lower socio-economic condition has been shown to have greater risk of rejection and graft loss among heart transplant recipients who survive the transplant hospitalization. However, the association of income status and in-hospital outcomes among heart transplant recipients have not been studied from a national database. MORE»

CVD IN WOMEN: A FRESH PERSPECTIVE
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Amsterdam
Ezra A. Amsterdam, M.D.
, University of California, Davis, CA, USA

Recognition that cardiovascular disease is the leading cause of mortality in women has stimulated major interest and improvement in the detection, prevention, and treatment of CVD in women. Certain aspects of this subject require further clarification and will be considered in this presentation. MORE»

USEFULNESS OF OPTICAL COHERENCE TOMOGRAPHY IN DAILY CLINICAL PRACTICE
(click on the photo to view the video)

Akasaka
Takashi Akasaka, M.D., Ph.D.
, Wakayama Medical University, Wakayama, Japan

Recently developed frequency-domain optical coherence tomography (FD-OCT) allow us to obtain 75mm length of high resolution intravascular image (10-20 micrometer) within 3 sec during contrast injection through a guiding catheter. This FD-OCT demonstrates the pathophysiology of the coronary atherosclerosis including vulnerable plaques with thin cap fibroatheroma (TCFA) in vivo before percutaneous intervention (PCI). MORE»

NEW STRATEGIES FOR ACUTE STROKE INTERVENTION
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Sievert
Horst Sievert, M.D., CardioVascular Center Frankfurt, Frankfurt, Germany

Stroke is the third leading cause of death and leading cause of disability in western countries. Though progress has been made in acute stroke intervention with the use of intravenous thrombolytic therapy, a large number of patients remain significantly disabled despite thrombolysis. MORE»

OPTICAL COHERENCE TOMOGRAPHY (OCT): WHAT YOU NEED TO KNOW
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Garcia
Joel A. Garcia, M.D., Denver Health Medical Center (DHMC) and University of Colorado Hospital at Denver, Denver, CO, USA

Objectives: Understanding the technical aspects of Optical Coherence Tomography (OCT) as they apply to daily clinical practice and comparing OCT images and acquisitions to intra-vascular ultrasound (IVUS). MORE»

THE COMPLICATED STEMI: WHAT TO DO WITH MULTIVESSEL DISEASE
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Barsness
Gregory W. Barsness, M.D., Mayo Clinic, Rochester, MN, USA

Primary PCI is the treatment of choice for the majority of patients presenting with myocardial infarction. In many instances, the choice of revascularization strategy is complicated by the presence of multivessel disease, especially in the presence of additional comorbidities, chronic total occlusions and, infrequently, hemodynamic or electrical instability. MORE»

PTEN AND STATINS INDUCED NEW ONSET DIABETES
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Birnbaum
Yochai Birnbaum, M.D., Baylor College of Medicine, Houston, TX, USA

Background: High-dose statin therapy increases the incidence of new-onset diabetes. Studies in animal models have suggested that prolonged statin therapy upregulates Phosphatase and Tensin Homologue on Chromosome 10 (PTEN) expression. PTEN levels are also elevated in the heart, aorta and skeletal muscles of animals with diabetes, as well as the myocardium of diabetic patients. MORE»

MAJOR NON-CARDIAC SURGERY IN PATIENTS WITH AORTIC STENOSIS - SAME AS 20 YEARS AGO?
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Pislaru
Sorin Pislaru, M.D., Ph.D., Mayo Clinic College of Medicine, Rochester, MN, USA

Severe aortic stenosis has been long recognized as a risk factor for perioperative mortality and morbidity. Current ACC/AHA Guidelines recommend that elective noncardiac surgery be postponed for AS patients until after aortic valve surgery, due to an estimated mortality risk of noncardiac surgery at approximately 10%. MORE»

FAILURE TO OVEREXPRESS UROCORTIN FOLLOWING CARDIOPLEGIC ARREST MAKES THE HEART OF DIABETIC PATIENTS UNDERGOING ON-PUMP CORONARY ARTERY BYPASS GRAFTING MORE SUSCEPTIBLE TO APOPTOSIS AND CARDIAC DYSFUNCTION
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Scarabelli
Tiziano M. Scarabelli, M.D., St John Hospital & Medical Center/Wayne State University SOM, Detroit, MI, USA

Background. Molecular mechanisms responsible for the reported worse outcome of diabetic patients (DMP) after on-pump cardiac surgery (OPCS) remain unknown. Opposite effects have been reported for Urocortin (Ucn)/PKCe and PKCd, the former being cardio-protective and the latter pro-apoptotic. MORE»



BEYOND HDL CHOLESTEROL: WHAT CAN WE LEARN FROM HDL PARTICLE NUMBER AND SIZE?
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Mora
Samia Mora, M.D., Brigham and Women's Hospital, Boston, MA, USA

Given the consistent inverse association of HDL cholesterol (HDL-C) with cardiovascular disease (CVD), there is immense interest in developing therapies that raise HDL-C. But HDL-C, the cholesterol carried by HDL particles, may not fully capture HDL-related cardioprotection. MORE»

THE ASSOCIATION BETWEEN DEPRESSION AND DIABETES
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Barrett-Connor
Elizabeth Barrett-Connor, M.D., UCSD Dept. of Family and Preventive Medicine, La Jolla, CA, USA

Depression increases the risk of mortality, shown in a 12-year follow-up of 10,025 U.S. NHANES adults (Egede LE, Diabetes Care, 2005). Because both diabetes and depression are common, there is considerable overlap by chance alone; a diagnosis of both is most likely to be made in hospitalized patients (Berkson’s bias). MORE»

CALIFORNIA REVASCULARIZATION: PCI OUTCOMES IN THE SUNSHINE STATE
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Bommer
William J. Bommer, M.D., University of California Davis, Medical Center, Davis, CA, USA

Introduction: In California (CA), 141 hospitals perform percutaneous coronary intervention (PCI) with 122 hospitals reporting to the NCDR® CathPCI registry. Objective: To evaluate the PCI volume and composite event outcomes in hospitals with surgery On-site versus hospitals with surgery Off-site in CA. MORE»

HDL AND THE ATHEROSCLEROSIS - MYTH OR REALITY
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Rosenson
Robert S. Rosenson, M.D.
, Mount Sinai Heart Mount Sinai School of Medicine, New York, NY, USA

Low HDL cholesterol (HDL-C) is an established biomarker for the future development of atherosclerosis and atherosclerotic cardiovascular disease (CVD) events in population-based observational studies and clinical trials of cholesterol-lowering therapies and this includes coronary heart disease (CHD) patients with low levels of LDL cholesterol (LDL-C) on statin therapy. MORE»

CARDIAC TISSUE HYPOTHYROIDISM- A MAJOR PLAYER IN DIABETIC CARDIOMYOPATHY
(click on the photo to view the video)

Gerdes
A. Martin Gerdes, M.D.
, N.Y. Weltman, New York Institute of Technology, Old Westbury, NY, USA

Objectives and Background: Thyroid dysfunction is common in individuals with diabetes mellitus (DM) and may contribute to the associated cardiac dysfunction. However, little is known about the extent and pathophysiological consequences of low thyroid conditions on the heart in DM. MORE»

OXIDATIVE-MECHANICAL SIGNALING ACTIVATES Wnt3a-Lrp5 MEDIATED AORTIC VALVE OSTEOGENESIS IN BICUSPID AORTIC VALVE DISEASE
(click on the photo to view the video)

Rajamannan
Nalini M. Rajamannan, M.D., Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Introduction: Calcific aortic valve disease (CAVD) is the most common indication for valve surgery in the USA. Cellular mechanisms are under intense investigation. This study hypothesizes that calcific aortic valve disease develops secondary to Wnt3a/Lrp5 activation via oxidative- mechanical stress via a tissue stem cell niche resident in the aortic valve. MORE»

FEMORAL OR RADIAL ACCESS FOR PRIMARY PCI: A DILEMMA OF CHOICE
(click on the photo to view the video)

Cheema
Asim N. Cheema, M.D., St. Michael's Hospital, Toronto, ON, Canada

Several studies have shown significant reduction in bleeding and vascular complications with transradial percutaneous coronary intervention (PCI) compared to a transfemoral approach. More recently, data from RIVAL and RIFLE-STEACS studies have suggested a mortality benefit in favor of transradial approach for patients undergoing PCI for ST elevation myocardial infarction (STEMI). MORE»

TRENDS IN MANAGEMENT AND OUTCOME OF PATIENTS WITH ACUTE CORONARY SYNDROMES IN THE LAST DECADE: THE ACS ISRAELI SURVEY (ACSIS) EXPERIENCE
(click on the photo to view the video)

Gottlieb
Shmuel Gottlieb, M.D.
, Jerusalem, Israel

Background: The management of acute coronary syndromes (ACS) patients has undergone major changes during the last decade. These changes reflect the results of numerous controlled clinical trials that established the basis for evidence-based guidelines. MORE»

NON-INVASIVE CARDIOVASCULAR IMAGING FOR EVALUATION OF CORONARY ARTERY BYPASS GRAFT DISEASE
(click on the photo to view the video)

Elhendy
Abdou Elhendy, M.D., Ph.D
, Department of Cardiology, Marshfield Clinic, Marshfield, WI, USA

Coronary artery bypass graft (CABG) surgery is a widely used method of revascularization in patients with severe coronary artery disease (CAD). Various studies have shown improvement of survival and cardiac symtoms after CABG, particularly in patients with low ejection fraction and multivessel CAD. MORE»

ADVANCES IN PATHOPHYSIOLOGY AND MANAGEMENT OF DIASTOLIC HEART FAILURE
(click on the photo to view the video)

Chatterjee
Kanu Chatterjee, M.B., FRCP
, The Carver College of Medicine, University of Iowa, Iowa City, IA, USA

Diastolic heart failure is defined as asyndrome of heart failure with preserved ejection fraction (HFPREF). In diastolic heart failure, left ventricular wall thickness and mass is increased and the cavity size is normal. The mass/cavity ratio is increased. MORE»

UPDATE ON THE TREATMENT OF LEFT MAIN DISEASE
(click on the photo to view the video)

Uretsky
Barry F. Uretsky, M.D.
, University of Arkansas for Medical Sciences, Little Rock, AR, USA

Percutaneous coronary intervention (PCI) with drug eluting stents (DES) has emerged as a treatment alternative with left main (LM) disease. Three randomized clinical trials (RCT) compared DES to coronary artery bypass surgery (CABG). MORE»

DUAL RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM INHIBITION: TOO MUCH OF A GOOD THING?
(click on the photo to view the video)

Danser
A.H. Jan Danser
, Erasmus MC, Rotterdam, The Netherlands

The beneficial effects of ACE inhibitors (ACEi) and AT1 receptor blockers (ARBs) are due to blockade of tissue Ang II. Such blockade is often incomplete, due to activation of feedback mechanisms within the RAS (‘Ang II escape’). MORE»

SURGICAL TIMING FOR INFECTIVE ENDOCARDITIS
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Kang
Duk-Hyun Kang, M.D., Asan Medical Center, Seoul, South Korea

Despite advances in medical and surgical treatment, infective endocarditis (IE) remains a serious disease that carries considerable mortality and morbidity. The role of surgery has been expanding in IE and early surgery is strongly indicated for IE patients with congestive heart failure or uncontrolled infection, but no randomized trial has been conducted to clarify the indications and optimal timing of surgery because of ethical, logistical and financial constraints. MORE»

INDICATIONS AND SURVIVAL OF 90 YEAR OLDS UNDERGOING CORONARY ANGIOGRAPHY
(click on the photo to view the video)

Sidhu Mandeep S. Sidhu, M.D., Albany Medical College, Albany, New York, USA

Background: The Elderly are the fastest growing segment of western population. 1 in 5 US Citizen will be elderly by the year 2030. Nonagenarians (>90 year old) are projected to grow to 18 million by the year 2050. MORE»

FLURPIRIDAZ F 18 PET VERSUS TC-99M SPECT FOR MYOCARDIAL PERFUSION IMAGING
(click on the photo to view the video)

Berman Daniel S. Berman, M.D., Cedars-Sinai Medical Center, Los Angeles, CA, USA

Flurpiridaz F-18, a new PET tracer for myocardial perfusion imaging has recently been studied in a Phase II trial. In pre-clinical and phase-I studies, flurpiridaz F-18 has shown essentially linear myocardial uptake throughout the range of flow. MORE»

 

 


Invited Speaker Presentations at the
17th World Congress on Heart Disease
(click on the photo to view the video)

GENETICS OF HEART DISEASE


GENETICS OF CORONARY ARTERY DISEASE

(click on the photo to view the video)

Roberts

Robert Roberts, M.D.
, University of Ottawa Heart Institute, ON, Canada

Susceptibility to coronary artery disease (CAD) is claimed to be 40-60% inherited, but until recently genetic risk factors predisposing to CAD have been elusive. Comprehensive prevention of CAD requires manipulation of genetic risk. The availability of microarrays of single nucleotide polymorphisms enabling genome-wide association studies (GWAS) led to the discovery of 33 genetic risk variants for CAD. MORE»

ISCHEMIC HEART DISEASE

 

PLATELETS AND INFLAMMATION

 

CARDIOPROTECTIVE THERAPIES


 

HEART FAILURE


IS THERE DIFFERENCES IN PATHOPHYSIOLOGY AND VENTRICULAR REMODELING BETWEEN SYSTOLIC AND DIASTOLIC HEART FAILURE
(click on the photo to view the video)

Chatterjee
Kanu Chatterjee, M.D., Medicine University of Iowa, Medicine University of California San Francisco, CA, USA

There are considerable differences in morphology, functional derangements and left ventricular remodeling. Differences in morphology: In systolic heart failure the ventricle dilated and spherical; In diastolic heart failure it is ellipsoidal and non-dilated. MORE»

PERIPARTUM CARDIOMYOPATHY: NEW CONCEPTS IN PATHOPHYSIOLOGY AND MANAGEMENT HEART FAILURE
(click on the photo to view the video)

Elkayam
Uri Elkayam, M.D.,
University of Southern California, Keck School of Medicine, Los Angeles, CA, USA

Peripartum cardiomyopathy(PPCM) is an ididopathic cardiomyopathy presenting with heart failure (HF) due to left ventricular systolic dysfunction towards the end of the pregnancy or in the months following delivery, where no cause of HF is found. A recent animal experimentation has shown that female mice with cardiomyocyte specific knockout of STAT3 developed PPCM. MORE»

ALCOHOL SEPTAL ABLATION VS. SEPTAL MYECTOMY FOR HOCM: WHEN TO DO WHICH
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Fifer
Michael A. Fifer, M.D.,
Massachusetts General Hospital, Boston, MA, USA

Alcohol septal ablation (ASA) was introduced in 1995 as an alternative to surgical septalmyectomy for patients with hypertrophic obstructive cardiomyopathy and symptoms refractory to optimal medical therapy. (No randomized comparative trials of ASA vs. myectomy have been done or planned. MORE»

 

MOLECULAR SURVIVAL AND REGENERATION


 

ARRHYTHMIA AND ELECTROPHYSIOLOGY


NEW INSIGHTS INTO IDENTIFICATION OF PATIENTS AT RISK FOR SUDDEN CARDIAC DEATH

(click on the photo to view the video)

Cain
Michael E. Cain, M.D.,
University at Buffalo, Buffalo, NY, USA

The annual incidence of sudden death (SCD) in the United States is between 184,000 and 462,000, with estimates that 50% to 70% of deaths are due to VT or VF. Availability of therapies that have been shown to reduce SCD in various at-risk groups, including beta-blockers, ACE- inhibitors, statins, aldosterone blockers, and the ICD, underscore the need to accurately identify patients who will develop VT/VF within some specified time period, and exclude those who will not experience SCD. MORE»

IS CARDIAC RESYNCHRONIZATION THERAPY PROARRHYTHMIC?
(click on the photo to view the video)

Curtis
Anne B. Curtis, M.D.,
University of Buffalo, Buffalo, NY, USA

Cardiac resynchronization therapy (CRT) is beneficial in the treatment of patients with systolic heart failure, New York Heart Association (NYHA) Class III-IV symptoms, left ventricular ejection fraction (EF) /=120 ms. CRT leads to improvement in EF and functional capacity, reverse ventricular remodeling, and better survival. MORE»

 

VALVULAR HEART DISEASE


THE IMPACT OF HYPERTENSION AND ITS TREATMENT IN HEART VALVE DISEASE
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Borer
Jeffrey S. Borer, M.D.,
State University of New York Downstate Medical Center, New York, NY, USA

Heart valve diseases cause chronic mechanical (volume and/or pressure) overloads. Beneficial relief of the overloads involves replacement or repair of severely dysfunctional valves, reducing impedance to chamber outflow when valves are stenotic, or reducing volume overload when valves are regurgitant. MORE»

THE ROLE OF LRP5 IN CALCIFIC AORTIC VALVE DISEASE: LDL-DENSITY-PRESSURE THEORY
(click on the photo to view the video)

Rajamannan
Nalini M. Rajamannan, M.D.,
Mayo Clinic, Rochester, MN, USA

Atherosclerosis and osteoporosis are the leading causes of morbidity and mortality in the World. Evidence indicates that hyperlipidemia plays a paradoxical role in both disease processes. However, the mechanism is not understood. The LDL-Density Pressure Theory hypothesizes the role of lipids activate atherosclerosis within the bone and the heart to initiate the development of diseases in both of these tissues. MORE»

 

HYPERTENSION

RENAL DENERVATION-STATE OF THE ART
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Bertog
Stefan C. Bertog, M.D.,
Cardiovascular Center Frankfurt, Germany

Systemic hypertension is a major burden to the individual and society. Its association with major adverse cardiac and cerebral events and favorable effects of antihypertensive therapy are undisputed. However, despite multidrug therapy, blood pressures are frequently suboptimally controlled. MORE»

 

 

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