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22nd World Congress on Heart Disease

 

 

 

 


22nd World Congress on Heart Disease


  IAC MEETINGS

 IAC

International Academy of Cardiology
Annual Scientific Sessions 2017
22nd World Congress on Heart Disease



vancouverThe Hyatt Regency Vancouver
Vancouver, BC, Canada
July 14 - 16, 2017

 

Abstract Deadline:
February 14, 2017


CME Meeting

Publication of Abstracts:
Accepted abstracts will be published in a special online only supplement issue of the journal CARDIOLOGY.

Affiliated with:
American College of Cardiology, California Chapter


The American Society for Preventive Cardiology

International Academy of Cardiovacular Sciences

International Academy of Cardiology
Annual Scientific Sessions 2016
21st World Congress on Heart Disease


bostonThe Westin Copley Place
Boston, MA, USA
July 30 - August 1, 2016

Final Scientific Program is now online.
Download as pdf.

CME Meeting

   
         
   
Video from the 16th World Congress on Heart Disease      
 
   
MEETINGS AFFILIATED WITH THE IAC

Controversies & Advances In The Treatment of Cardiovascular Disease: The Sixteenth in the Series
November 17-18, 2016
Beverly Hills, CA, USA



 

 


To see more information on Meetings Offered in Cooperation with the International Academy of Cardiology, click here.

 


 
 PREVIOUS MEETINGS OF THE IAC
 

International Academy of Cardiology
Annual Scientific Sessions 2015
20th World Congress on Heart Disease



vancouverHyatt Regency Vancouver
Vancouver, BC, Canada
July 25-27, 2015


CME Meeting

The scientific program of the International Academy of Cardiology, Annual Scientific Sessions 2015, 20th World Congress on Heart Disease has been approved by the American Medical Association for 22.75 AMA PRA Category 1 Credits™.

Photo Gallery.new

Scientific Program.
Download as pdf.

Publication of Abstracts:
Accepted abstracts were published in a special online only supplement issue of the journal CARDIOLOGY.


boston International Academy of Cardiology
Annual Scientific Sessions 2014
19th World Congress on Heart Disease


Hyatt Regency, Boston, MA, USA
July 25-28, 2014

CME Meeting


Photos from the 19th World Congress on Heart Disease (click here to see more photos)

Photo Gallery now online. new


toronto
International Academy of Cardiology
18th WORLD CONGRESS ON HEART DISEASE
Annual Scientific Sessions 2013

July 26-29, 2013
Hyatt Regency, Vancouver, BC, Canada

CME Meeting
Photo Gallery


 


Photos from the 18th World Congress on Heart Disease (click here to see more photos)

   toronto 

International Academy of Cardiology
17th WORLD CONGRESS ON HEART DISEASE

Annual Scientific Sessions 2012
July 27-30, 2012
The Fairmont Royal York,
Toronto, ON, Canada

 

 

Photos from the 17th World Congress on Heart Disease
(Click here to see more photos)

      
International Academy of Cardiology
16th WORLD CONGRESS ON HEART DISEASE

Annual Scientific Sessions 2011
July 23-26, 2011
Hyatt Regency Vancouver, BC, Canada

 

photos Click here to view photos from the 16th World Congress on Heart Disease


New Horizons in Cardiovascular Disease15th WORLD CONGRESS ON HEART DISEASE
International Academy of Cardiology
Annual Scientific Sessions 2010

July 24-27, 2010
Vancouver, BC, Canada

(click to view index as pdf)

Proceedings Book
ISBN: 978-88-7587-617-3


Photos from the 15th World Congress on Heart Disease
(Click here to see more photos)




Current Advances in Heart Disease14th WORLD CONGRESS ON HEART DISEASE
International Academy of Cardiology
Annual Scientific Sessions 2008

July 26-29, 2008
Toronto, ON, Canada

(click to view index as pdf)

Proceedings Book
ISBN: 978-88-7587-480-3

Recent Advances in Cardiovascular Disease 13th WORLD CONGRESS ON
HEART DISEASE

International Academy of Cardiology
Annual Scientific Sessions 2007
July 28 - 31, 2007
Hyatt Regency Vancouver
Vancouver, B.C., Canada

Proceedings Book
ISBN: 978-88-7587-369-1


Photos from the 13th World Congress on Heart Disease
(Click here to see more photos)





Advances in Heart Disease INTERNATIONAL ACADEMY OF CARDIOLOGY
12th WORLD CONGRESS ON HEART DISEASE
- NEW TRENDS IN RESEARCH, DIAGNOSIS AND TREATMENT
July 16-19, 2005
Vancouver, BC, Canada


Proceedings Book
ISBN: 88-7587-192-2


 Photos from the
12th World Congress on Heart Disease

[Click here to see more photos]




To see more information on Previous IAC Meetings, click here.

 

PREVIOUS MEETINGS AFFILIATED WITH IAC

20th Annual Heart Failure 2016 - Update on Diagnosis and Therapy
April 16, 2016
Los Angeles, CA, USA

The 4th International Congress on Cardiac Problems in Pregnancy (CPP2016)
February 27 - March 1, 2016
Las Vegas, Nevada, USA

Advances in Nuclear Cardiology and Cardiac CT: 31th Annual Case Review with the Experts with 101 Evidence-based Cases
January 22-24, 2016
Cedars-Sinai Medical Center
Los Angeles, CA, USA

Controversies and Advances in the Treatment of Cardiovascular Disease, the Fifteenth in the Series
November 19-20, 2015
Beverly Hills, CA, USA




International Congress on Echocardiography - “ECHO of the White Nights-2015”

September 17-19, 2015
St. Petersburg, Russia




4th Annual Cardiovascular Disease Prevention Conference (American Socity for Preventive Cardiology)
July 31 - August 2, 2015
Boca Raton, FL, USA


To see more information on Previous Meetings Under the Auspices of the International Academy of Cardiology, click here.

 

  CARDIOLOGY ONLINE NEWS

Invited Speaker Presentations at the IAC Annual Scientific Sessions 2014, 19th World Congress on Heart Disease, Boston, MA, USA
(click on the photo to view the video)


 
19th WORLD CONGRESS ON HEART DISEASE

2014 UPDATE ON MANAGEMENT OF HYPERTENSION
Aronow
Wilbert S. Aronow, M.D., Westchester Medical Center/New York Medical College, Valhalla, NY, USA

The ACC/AHA 2011 expert consensus document on hypertension in the elderly recommended the blood pressure (BP) in patients with primary hypertension or in patients at high risk for cardiovascular events such as those with coronary heart disease, stroke, peripheral arterial disease, diabetes, chronic kidney disease, and heart failure be less than 140/90 mm Hg in adults with hypertension younger than 80 years and the systolic BP reduced to 140-145 mm Hg if tolerated in persons with hypertension aged 80 years and older. MORE»
 

PRESENT AND FUTURE OF NUCLEAR CARDIOLOGY AND CARDIAC CT IN CAD: VALUE-BASED IMAGING
Berman
Daniel S. Berman, M.D., Cedars Sinai Medical Center, Los Angeles, CA, USA

The future use SPECT or PET, and cardiac CT will be based on their providing value by improving quality (e.g., reducing events) or decreasing costs. For prevention, coronary calcium scanning can provide value, guiding management more effectively than risk factors or other biomarkers. MORE»

 

 

GI PROTEINS, NATRIURETIC PEPTIDE RECEPTOR C AND REGULATION OF BLOOD PRESSURE
Anand-Srivastava
Madhu B. Anand-Srivastava, Ph.D., University of Montreal, Montreal, Quebec, Canada

C-ANP4-23, a ring deleted analog of atrial natriuretic peptide (ANP) that specifically interacts with natriuretic peptide receptor-C has been shown to decrease the enhanced expression of Gialpha proteins, implicated in the pathogenesis of hypertension. MORE»

 

MANAGING ANGINA AND RISK VIA IMPROVED ENDOTHELIAL FUNCTION: THE EECP MODEL
Barsness
Gregory Barsness, M.D., Mayo Clinic, Rochester, MN, USA

Enhanced external counterpulsation (EECP) is an outpatient therapy for the treatment of stable ischemic heart disease, angina and heart failure. Although a non-invasive therapy, EECP treatment produces a marked acute hemodynamic effect similar to that produced by the invasive intra-aortic balloon pump. MORE»

 

TICAGRELOR LIMITS MYOCARDIAL INFARCT SIZE- AN ADENOSINE AND COX2 DEPENDENT EFFECT
Birnbaum
Yochai Birnbaum, M.D., Baylor College of Medicine, Texas, USA

In a phase III clinical trial (PLATO) Ticagrelor (TIC) showed better clinical outcomes than Clopidogrel (CLOP) in patients with acute coronary syndromes. In addition to P2Y12 receptor antagonism, TIC prevents cell uptake of adenosine and thus, may augment adenosine effects. MORE»

 

 

AORTIC REGURGITATION: IMPACT OF PREOPERATIVE SYMPTOMS FOR POST-VALVE REPLACEMENT SURVIVAL ON PROGNOSTICATION FROM MYOCARDIAL CONTRACTILITY
Borer
Jeffrey S. Borer, M.D., State University of New York Downstate Medical Center, New York, NY, USA

Both preoperative symptoms and severe preoperative myocardial contractility deficit predict survival among patients (pts) undergoing aortic valve replacement (AVR) for aortic regurgitation (AR). The interactive effects of these predictors are unknown. MORE»

SERENDIPITY IN MEDICINE; DOES CHANCE TRULY FAVOR THE PREPARED MIND?
Biederman
Robert W.W. Biederman, M.D. , Carnegie Mellon University, Allegheny General Hospital, Pittsburgh, PA, USA

Serendipity means a "fortuitous happenstance" or "pleasant surprise". It was first coined by Horace Walpole in 1754. In a letter he wrote to a friend Walpole explained an unexpected discovery he had made by reference to a Persian fairy tale, The Three Princes of Serendip. MORE»


SUCCESSFUL EVAR PROGRAM FOR AAA IN A RURAL HOSPITAL
Butman
Samuel M. Butman, M.D., Verde Valley Medical Center, Cottonwood, AZ, USA

Endovascular aortic aneurysm repair is now widely accepted as the preferred method of mitigating the risk of rupture in patients with documented abdominal aneurysms. Beginning in higher volume centers, the procedure is now performed in smaller community hospitals. MORE»

PREDICTION OF ARRHYTHMIC EVENTS WITH POSITRON EMISSION TOMOGRAPHY
Cain
Michael E. Cain, M.D., University at Buffalo, Buffalo, NY, USA

Between 184,000 and 462,000 Americans die suddenly each year. Fifty to seventy percent of these deaths are due to ventricular tachycardia/ fibrillation (VT/VF). We tested whether hibernating myocardium or myocardial sympathetic denervation identifies patients at high-risk for developing VT/VF independently of EF. MORE»


THE ROLE OF PROGENITOR CELLS IN ATHEROSCLEROSIS
Caplice
Noel M. Caplice, M.D., Ph.D., University College Cork, Cork. Ireland

We previously showed that circulating cells with smooth muscle outgrowth potential exist in the peripheral circulation and that bone marrow derived precursor cells contribute to smooth muscle cells within murine and human atherosclerotic plaque. More recently we have defined a myeloid subpopulation of cells that undergo smooth muscle cell differentiation following signalling through the CX3CR1 chemokine receptor. MORE»

LOW GRADIENT SEVERE AORTIC STENOSIS: DIAGNOSIS AND MANAGEMENT
Chaliki
Hari P. Chaliki, M.D., Mayo Clinic, Arizona, USA

According to the most recent ACC/AHA guidelines, peak velocity greater than 4 m/sec, a mean gradient of more than 40 mmHg and a valve area of less than 1.0 cm2 is considered severe aortic stenosis (AS). Aortic valve surgery should be done promptly in symptomatic patients or patients with reduced left ventricular ejection fraction with severe AS because of a dismal prognosis without operation. MORE»


DUAL UTILIZATION OF EXERCISE ECHOCARDIOGRAMS AND MYOCARDIAL PERFUSION IN ASSESSING ISCHEMIA IN A CARDIOLOGY PRACTICE
Charuzi
Yzhar Charuzi, M.D., Cedars Sinai Heart Institute, Los Angeles, CA, USA

In patients with suspected ischemia, the data derived from one type of imaging test may be insufficient to assess its significance. In 62 patients, two imaging techniques were utilized to assess the extent of ischemia and help determine clinical management. MORE»

CLINICAL EFFECTIVENESS OF CRT AND ICD THERAPY IN PATIENTS WITH HEART FAILURE BY RACE AND GENDER: FINDINGS FROM IMPROVE HF
Curtis
Anne B. Curtis, M.D., University at Buffalo, Buffalo, NY, USA

Clinical trials have demonstrated benefit for cardiac resynchronization therapy and implantable cardioverter defibrillator therapies in patients with heart failure and reduced ejection fraction, yet questions have been raised with regard to the benefit of device therapy for women and minorities. MORE»


DUAL AT1 RECEPTOR/NEPRILYSIN INHIBITION ('ARNI') IN HYPERTENSION: AN IMPROVEMENT VERSUS AT1 RECEPTOR BLOCKADE?
Danser
A.H. Jan Danser, M.D., Erasmus Medical Center, Rotterdam, The Netherlands

Neprilysin inhibitors (NEPi) prevent natriuretic peptide breakdown, thereby promoting vasodilation and natriuresis. On the other hand, they increase angiotensin and endothelin-1. The combined NEP/ACE inhibitor omapatrilat displayed potent effects in hypertension and heart failure, but these were accompanied by the occurrence of angioedema due to bradykinin accumulation. MORE»

POTENTIAL THERAPY FOR THE PREVENTION OF SUDDEN CARDIAC DEATH
Dhalla
Naranjan S. Dhalla, Ph.D., M.D.(Hon), St. Boniface General Hospital Research Centre, University of Mantioba, Winnipeg, Canada

Although sudden cardiac death is a leading cause of mortality, the mechanisms for its pathogenesis as well as therapy for prevention are poorly understood. Background: Since overactivation of sympathetic nervous system is invariably seen in subjects with high risk for sudden cardiac death, elevated levels of circulating catecholamine levels are considered to result in lethal ventricular arrhythmias and subsequent sudden cardiac death. MORE»


MITOCHONDRIAL DYSFUNCTION AND ARRHYTHMIC RISK: POSSIBLE NEW THERAPIES FOR SUDDEN DEATH
Dudley
Samuel C. Dudley, M.D., Ph.D., Brown University and Lifespan Cardiovascular Institute, Providence, RI, USA

Mitochondria are essential to providing ATP thereby satisfying the energy demand of the incessant electrical activity and contractile action of cardiac muscle. Emerging evidence indicates that mitochondrial dysfunction can adversely affect cardiac electrical functioning by impairing the intracellular ion homeostasis and membrane excitability through reduced ATP production and excessive reactive oxidative species generation, resulting in increased propensity to cardiac arrhythmias. MORE»

FUNCTIONAL AND ANATOMICAL CARDIAC IMAGING IN PATIENTS WITH CORONARY ARTERY STENTS
Elhendy
Abdou Elhendy, M.D., Ph.D., Marshfield Clinic, Marshfield, WI, USA

Coronary artery stenting has been shown to improve myocardial function, and ameliorate angina. The number of complex interventional procedures has recently increased due to technical advances. However, myocardial perfusion may be compromised after coronary stenting by acute thrombosis or the development of fibrointimal hyperplasia leading to decline in left ventricular function and increased risk of myocardial infarction. MORE»


REGRESSION OF HYPERTROPHY (AND FIBROSIS?) IN HYPERTROPHIC CARDIOMYOPATHY
Fifer
Michael A. Fifer, M.D., Massachusetts General Hospital, Boston, MA, USA

Left ventricular hypertrophy and fibrosis are important determinants of morbidity and mortality in hypertrophic cardiomyopathy. Regression of hypertrophy remote from the interventricular septum is observed after septal reduction therapy with myectomy or alcohol ablation. MORE»

TOLL-LIKE RECEPTOR 9 REGULATION OF COAGULATION IN ACUTE CORONARY ARTERY DISEASE
Filep
Janos G. Filep, M.D., Maisonneuve-Rosemont Hospital, Montreal, Quebec, Canada

Bacteriemia has recently been reported to be associated with increased risk of acute coronary artery disease and stroke. Bacterial DNA containing unmethyled CpG dinucleotide motifs is potent inducer of immune responses predominantly through Toll-like receptor 9. MORE»


A CASE OF ORTHOSTATIC HYPOTENSION AND RECENT ADVANCES
Fung
Gordon L. Fung, M.D., M.P.H., Ph.D., UCSF Medical Center at Mt. Zion, San Francisco, CA, USA

JM is a 78 year old man who had a history of hypertension and developed an ascending aortic aneurysm while under treatment. He presented to the hospital for elective prostate operation and was seen by Cardiology for evaluation of atypical chest pain. The patient gave a history of recurrent syncope over the past 6 years with syncope every 1-2 years. MORE»

MOLECULAR DRIVERS OF VASCULAR REMODELING
Galis
Zorina Galis, Ph.D., Division of Cardiovascular Sciences, NIH, Bethesda, MD, USA

During their natural history, blood vessels undergo enduring, and sometimes irreversible structural changes in size and composition, a process commonly referred to as vascular remodeling. Many of these changes are initiated as a physiological response allowing adaptation and repair of the vessel wall, however inappropriate remodeling underlies the pathogenesis of major cardiovascular conditions, such as atherosclerosis, hypertension, or aneurysmal disease. MORE»


MANAGEMENT OF STABLE ISCHEMIC HEART DISEASE: OVERVIEW OF RECENT GUIDELINES
Gardin
Julius M. Gardin, M.D., Hackensack University Medical Center, NJ, USA

Management guidelines regarding diagnosis and treatment of stable ischemic heart disease (SIHD) have evolved with time. In 2012, the ACCF/AHA/ACP SIHD Guidelines (Fihn, Gardin, et al.) emphasized important concepts, e.g., the following: (1) Most SIHD patients should have a trial of guideline-directed medical therapy, including risk factor modification, before considering revascularization to improve symptoms. MORE»

TRANSLATING T3 TREATMENT OF HEART FAILURE FROM BENCH TO BEDSIDE: FINALLY, A SAFE TREATMENT/MONITORING PROTOCOL THAT SHOULD WORK!
Gerdes
A. Martin Gerdes, Ph.D., New York Institute of Technology, Old Westbury, NY, USA

The idea of treating heart failure with thyroid hormones (THs) is not new. Unfortunately, cardiovascular clinical studies mostly using TH analogs at excessive doses demonstrated an increased incidence of arrhythmias and have largely deterred further studies. At the heart of the problem, no one has clearly demonstrated potential benefits using a therapeutic TH treatment/monitoring protocol that can be safely translated to humans. MORE»


CAN WE PREVENT HEART FAILURE READMISSIONS?
Heidenreich
Paul A. Heidenreich, M.D., Stanford University, Palo Alto, CA, USA

Readmissions are common following an admission for heart failure occurring in 20-30% of patients within 30 days of discharge. Many payers including U.S. Medicare have estimated that a large fraction of these readmissions are preventable (up to 75%). MORE»

GUIDING PRINCIPLES IN STATIN UTILIZATION: EMERGING CLINICAL AND PUBLIC HEALTH CHALLENGES
Hennekens
Charles H. Hennekens, M.D., Dr.P.H., Florida Atlantic University, Boca Raton, FL, USA

The current totality of evidence on statins in treatment and prevention of cardiovascular disease includes 170,000 secondary prevention and high risk primary prevention patients. Those assigned at random to a statin had statistically significant and clinically important reductions in myocardial infarction of 30%, stroke of 15%, the need for stents and coronary artery bypass grafts of 25% and coronary death of 22%. MORE»


SLEEP-TIME BLOOD PRESSURE AS A THERAPEUTIC TARGET FOR CARDIOVASCULAR RISK REDUCTION
Hermida
Ramon C. Hermida, Ph.D., Campus Universitario, Vigo, Pontevedra, Spain

Diagnosis of hypertension and clinical decisions regarding its treatment are typically based upon clinic blood pressure (BP) measurements, occasionally supplemented by wake-time patient self-assessment. Yet, correlation between BP level and target organ damage, cardiovascular disease risk, and long-term prognosis is greater for ambulatory BP monitoring than daytime in-clinic measurements. MORE»

COLCHICINE AND NEW MANAGEMENT STRATEGIES FOR ACUTE AND RECURRENT PERICARDITIS
Imazio
Massimo Imazio, M.D., Maria Vittoria Hospital, Torino, Italy

Bacteriemia has recently been reported to be associated with increased risk of acute coronary artery disease and stroke. Bacterial DNA containing unmethyled CpG dinucleotide motifs is potent inducer of immune responses predominantly through Toll-like receptor 9. MORE»


A CASE OF ORTHOSTATIC HYPOTENSION AND RECENT ADVANCES
Jezova
Daniela Jezova, M.D., Slovak Academy of Sciences, Bratislava, Slovakia

In comparison to coronary heart disease, the pathogenic mechanisms in stroke are very heterogeneous and reliable biomarkers to predict stroke severity and outcome are not available yet. The activation of neuroendocrine functions, particularly those involved in the stress response, represent important aspects of stroke pathophysiology. MORE»

COLCHICINE AND NEW MANAGEMENT STRATEGIES FOR ACUTE AND RECURRENT PERICARDITIS
Jo
Hanjoong Jo, Ph.D., Dept. of Biomedical Engineering, Emory University, Atlanta, GA, USA

Atherosclerosis is the major underlying cause of myocardial infarction and stroke and preferentially occurs in arterial regions exposed to disturbed flow (d-flow) by mechanisms involving broad changes in gene expression. We have shown that D-flow rapidly induces atherosclerosis in vivo using a mouse partial carotid ligation model. MORE»


FRACTIONAL FLOW RESERVE (FFR) AT 2014- WHERE ARE WE AND WHERE IS IT GOING
Kaluski
Edo Kaluski, M.D., University Hospital, Newark, NJ, USA

New society guidelines support now the use of FFR over to assess intermediate stable native coronary lesions (now defined as 50-90% diameter stenosis when stress imaging is contraindicated, non-diagnostic, discordant or unavailable. MORE»

CARDIORENAL SYNDROME: NOT AS STRAIGHT FORWARD AS WE USED TO THINK
Kazory
Amir Kazory, M.D., University of Florida, Gainesville, FL, USA

Simultaneous dysfunction of the heart and the kidney represents a distinct spectrum of disease states composed of complex clinical scenarios with potentially adverse outcomes. Worsening renal function in the setting of acute decompensated heart failure is one such clinical setup with not yet well-characterized underlying mechanisms. MORE»


THE EFFECT OF BENDAVIA ON ISCHEMIA/REPERFUSION INJURY, LEFT VENTRICULAR REMODELING AND DYSFUNCTION
Kloner
Robert A. Kloner, M.D., Ph.D., Good Samaritan Hospital/USC, Los Angeles, CA, USA

Bendavia is a small water soluble molecule that freely crosses cell membranes and localizes to the inner mitochondrial membrane where it associates with cardiolipin and reduces intracellular reactive oxygen species production. Our objective was to determine Bendavia’s effect on myocardial infarction. MORE»

INNATE IMMUNITY AND HEART DISEASE
Knowlton
Anne A. Knowlton, M.D., University of California, Davis, CA, USA

The innate immune system is a primitive, rapid immune response that responds to detected threats by producing a rapid inflammatory response. A series of pattern recognition receptors recognizes molecular patterns (pathogen associated molecular patterns or PAMPs) that are common to microbes and to danger signals (damage-associated molecular patterns or DAMPs) from injured cells. MORE»


NON PHARMACOLOGICAL AND CATHETER BASED THERAPY OF DIFFICULT TO TREAT (D2T) HYPERTENSION
Koshy
Santhosh K. Koshy, M.D., UT Health Sciences Center, Memphis, TN, USA

Resistant or difficult to treat hypertension is not uncommon and is a nightmare for both primary care physicians and specialists. It is defined as an uncontrolled hypertension with blood pressure consistently above 140/90mmHg despite adequate regimen with four or more anti-hypertensives, preferably with one that includes a diuretic. MORE»

PCI VERSUS CABG IN MULTIPLE VESSEL CAD
Kumar
Adarsh Kumar, M.D., Govt Medical College/GND Hospital, Amritsar, India

CAD is number one killer in the world. CABG and PCI are both safe and established invasive treatment modalities for CAD. However conflicting information exists when comparing their long term efficacy in multiple vessel disease. MORE»


METABOLIC SYNDROME CRITERIA: CAUSE VERSUS EFFECT OF CARDIOMETABOLIC DISEASE
Levine
T. Barry Levine, M.D., Drexel University College of Medicine, Philadelphia, PA, USA

Although metabolic syndrome (MetSyn)-criteria provide a convenient tool to recognize individuals at increased cardiometabolic disease-risk, they appear haphazard, mixing descriptors of body-phenotype with lab-tests and a vascular condition. Are MetSyn-criteria causes or effects? MORE»

MITOCHONDRIAL DYSFUNCTION AND DIABETIC HEART DISEASE
Liang
Qiangrong Liang, M.D., Ph.D., New York Institute of Technology, Old Westbury, NY, USA

Most diabetic patients die from heart disease or stroke, highlighting the importance of understanding and treating cardiovascular complications of diabetes. A large body of evidence indicates that mitochondrial dysfunction and increased generation of reactive oxygen species (ROS) are critical to diabetic heart damage. MORE»


CARBON NANOTUBES SCAFFOLDS AS A NEW BASIS FOR CARDIAC TISSUE ENGINEERING
Long
Carlin S. Long, M.D., University of Colorado Health Sciences Center, Denver Health Medical Center, Denver, CO, USA

In our previously published work we reported that MWCNTs used as growth supports for culturing neonatal rat ventricular myocytes increase myocyte proliferation and induce a more negative resting potential, suggesting that carbon nanotubes promote cardiomyocyte maturation. However, the mechanistic link between the enhanced cardiomyocyte proliferation and maturation and carbon nanotubes interaction was unknown. MORE»

USE OF FRACTION FLOW RESERVE TO PREDICT CHANGES OVER TIME IN MANAGEMENT OF SUPERFICIAL FEMORAL ARTERY
Lotfi
Amir S. Lotfi, M.D., Tufts University School of Medicine, Baystate Medical Center, Springfield, MA, USA

Peripheral arterial disease is a condition characterized by progressive narrowing of the arteries in the peripheral vascular bed which affect patient quality of life. The purposes of this study were to 1) establish the feasibility of performing peripheral FFR (pFFR) in the peripheral vascular circulation, 2) correlate post intervention pFFR with future restenosis, and 3) demonstrate an association between pFFR and peak systolic velocity measured by duplex ultrasound. MORE»


TRIGGERS OF ACUTE CARDIOVASCULAR EVENTS: CLINICAL IMPLICATIONS
Madjid
Mohammad Madjid, M.D., Texas Heart Institute, Houston, TX, USA

Atherosclerotic cardiovascular events result from two separate phases of mechanistic processes. Whereas lipid accumulation and chronic latent inflammation lead to development of atherosclerotic plaques over a period of years, certain internal or external factors can “trigger” the transformation of stable plaques into unstable plaques within hours to weeks, causing an acute coronary syndrome (ACS). MORE»

STRESS-ONLY IMAGING; A NEW PARADIGM FOR PERFORMING STRESS MYOCARDIAL PERFUSION IMAGING
Mahmarian
John J. Mahmarian, M.D., Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas, USA

There have been continued efforts over the past several years to utilize a patient-centered imaging approach when performing stress myocardial perfusion imaging. One such approach has been to choose a single day stress/rest imaging strategy so that if the stress study is normal, rest imaging is unnecessary. MORE»


PRECISION MEDICINE FOR TODAY AND TOMORROW: TARGETING MOLECULAR PATHWAYS FOR VASCULAR DISEASE
Maiese
Kenneth Maiese, M.D., University of Medicine & Dentistry of New Jersey, Newark, NJ, USA

Molecular targeting is becoming increasing recognized as a necessary means for drug development and the successful treatment of an individual’s disease onset and progression. Although multiple pathways can be responsible for cardiac or vascular disorders in patients, kinase pathways in the vascular system that involve phosphoinositide 3-kinase, protein kinase B, and the mammalian target of rapamycin offer especially exciting prospects for developing strategies for disease in the cardiovascular system. MORE»

WOMEN AND HEART DISEASE: UPDATE ON PREVENTION
Malik
Shaista Malik, M.D., Ph.D., M.P.H., University of California, Irvine, CA, USA

Cardiovascular disease remains the leading killer of both men and women in the United States. However, compared to men, women have higher rates of morbidity and mortality secondary to cardiovascular disease. MORE»


THE PIVOTAL ROLE OF L-ARGININE IN THE ISCHEMIC HEART PRECONDITIONING - A NANOMEDICAL APPROACH
Malinski
Tadeusz Malinski, Ph.D., Dr.h.c.m., Ohio University, Athens, OH, USA

Ischemic preconditioning with a short coronary artery occlusion has been shown to protect the heart against a subsequent myocardial infarction. Although several endogenous molecules have been implicated in the heart adaptation to an ischemic event, its mechanism is not well understood. A nanomedical approach was used to study, in vivo and ex vivo, the concentration changes of small molecules in the heart during preconditioning. MORE»

TEMPORAL VARIATION IN ACUTE AORTIC DISEASES: ONLY A RANDOM PHENOMENON?
Manfredini
Roberto Manfredini, M.D., University of Ferrara, Italy

Chronobiology is a branch of biomedical sciences devoted to the study of biological rhythms, that according to cycle length, are classified into: circadian (period of around 24 hours), ultradian (less than 24 hours), and infradian (more than 24 hours, e.g., days, weeks, months), and their interactions with bodily functions. MORE»


DEMOGRAPHIC CHANGES IN CONGENITAL HEART DISEASE IN THE XXI CENTURY: IMPACT IN MANAGEMENT AND OUTCOMES
Marelli
A.J. Marelli, M.D., M.P.H., Mc Gill University Health Centre, Montreal, QC, Canada

The field of complex congenital heart disease has evolved greatly, allowing for more patients to survive into adulthood. Emerging is a new era of changing demographics that must be matched with services and infrastructures commensurate with its growth. MORE»

 

TRAINING OF CARDIOVASCULAR PHYSICIAN-SCIENTISTS: RESULTS OF SPECIFIC TRAINING PATHWAYS
Marsh
James D. Marsh, M.D. , University of Arkansas for Medical Sciences, Little Rock, AR, USA

Physician-scientists play a crucial role in biomedical research in the United States. However, the number and portion of MD’s who commit a major portion of their professional time to research and who receive major external funding is diminishing. MORE»


PREVENTION OF STROKE IN ATRIAL FIBRILLATION: ARE ALL ORAL DRUGS THE SAME?
Martinez Rubio
Antoni Martinez-Rubio, M.D., Ph.D., University Hospital of Sabadell (Univ Autonoma de Barcelona), Sabadell, Spain

Prevention of thromboembolic events using oral anticoagulant drugs (OAC) is mandatory in several patients with atrial fibrillation. Therefore, OAC have been developed and used since decades. However, efficacy of these must be well balanced with the risk of inherent bleeding complications. MORE»

 

SATURATED FAT INTAKE AND THE GENESIS OF CORONARY ARTERY DISEASE – WHERE’S THE EVIDENCE?
Mehta
Jawahar L. Mehta, M.D., Ph.D. University of Arkansas for Medical Sciences, Little Rock, AR, USA

Dietary saturated fat intake has long been blamed for causing coronary artery disease based on scant epidemiological data. However, little evidence supports the notion that reducing saturated fat intake would reduce coronary artery disease. MORE»


STEM CELL AND GENE THERAPY FOR HEART FAILURE
Miller
Leslie W. Miller, M.D., University of South Florida, Tampa, FL, USA

The number of patients with advanced heart failure who are still symptomatic despite optimized medical therapy continues to increase. Therapeutic options for this population have been limited to heart transplant or use of LVADs. MORE»

 

 

INTEGRATIVE AND COMPLEMENTARY MEDICINE IN CARDIOLOGY: NEW HOPE OR JUST HIP AND HYPE?
Mody
Freny V. Mody, M.D., VA Greater Los Angeles HCS, CA, USA

Objectives: To review rigorous scientific evidence of benefit and effective treatments in integrative medicine (IM) for cardiovascular disease (CVD). IM integrates traditional medicine with non-conventional therapeutic modalities referred to as complementary alternative medicine (CAM). MORE»


CARDIAC SURGERY IN THE ADULT CONGENITAL HEART DISEASE PATIENT: A SPECTRUM OF LESIONS
MoraBassem N. Mora, M.D., Sheikh Khalifa Medical City, Cleveland Clinic, Abu Dhabi, United Arab Emirates

Objectives: To discuss the spectrum of anomalies which require cardiac surgery in the adult congenital heart disease (ACHD) patient. Background: There are >1,000,000 ACHD patients in North America. Cardiac surgery in those is divided into three categories MORE»

 

RESIDUAL VASCULAR RISK AFTER STATIN THERAPY: THE PROMISE OF NOVEL LIPOPROTEIN BIOMARKERS
Mora
Samia Mora, M.D., M.H.S., Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Statins are the most widely used lipid-lowering agents and the standard of care for individuals with dyslipidemia, prior CVD, or at high-risk for CVD. However, the risk among statin-treated individuals remains high and has been termed “residual risk”. MORE»


INDOXYL SULFATE AND CARDIO-RENAL SYNDROME; THE ROLE OF ARYL HYDROCARBON RECEPTOR
MoritaToshisuke Morita, M.D., Ph.D., Toho University Omori Medical Center, Ota-ku, Tokyo, Japan

The aim of this lecture is to discuss research involving the ligand of the aryl hydrocarbon receptor (AhR) and their role in cardio-renal syndrome. AhR is a ligand-activated nuclear receptor/transcription factor belonging to the basic helix-loop-helix/per-AhR nuclear translocator-Sim family of proteins. MORE»

 

UPDATE ON CORONARY BIFURCATION CLASSIFICATION AND TECHNIQUES
Movahed
Mohammad R. Movahed, M.D., Ph.D., The Southern Arizona VA Health Care System, Tucson, AZ, USA

There are many classifications for coronary bifurcation lesions. This talk will focus on most comprehensive classification of bifurcation lesions that is simple, practical and inclusive of other important features of coronary bifurcation lesions that are not mentioned in other classifications. MORE»


MECHANISMS OF HYPERTROPHY IN VALVULAR HEART DISEASE
OlsenNiels T. Olsen, M.D., Ph.D., Rigshospitalet, Copenhagen, Denmark

Myocardial hypertrophy has a prominent role in valvular heart disease. The evaluation of hypertrophy is invaluable when determining the hemodynamic significance of a valve lesion, as the myocardium responds to increased load from regurgitant or stenotic valve lesions with growth in predictable patterns. MORE»

 

MEDITERRANEAN DIET AND SECONDARY PREVENTION OF CVD
Panagiotakos
Demosthenes B. Panagiotakos, Ph.D., Harokopio University, Athens, Greece

Adherence to a healthy dietary pattern, such as the Mediterranean diet, exerts a beneficial role regarding the development of coronary heart disease. In addition, several studies support the protective role of the Mediterranean diet as far as secondary prevention of CVD is concerned.MORE»


GENETIC DISRUPTION OF NPR1 UPREGULATES CARDIAC EXPRESSION OF PROINFLAMMATORY MEDIATORS
PandeyKailash N. Pandey, Ph.D. Tulane University School of Medicine, New Orleans, LA, USA

Proinflammatory cytokines play a central role in the pathophysiology and development of endothelial dysfunction, cardiac hypertrophy, and heart failure in experimental animal models and humans. MORE»

 

MANAGEMENT OF ATRIAL FLUTTER
Paydak
Hakan Paydak, M.D., University of Arkansas for Medical Sciences, Little Rock, AR, USA

Atrial flutter affects nearly 1 million people in the United States, particularly the older age group and men. It is frequently seen in patients with heart failure, hypertension, diabetes mellitus, COPD and in postoperative states. MORE»


HAND HELD CARDIAC ULTRASOUND: ROLE IN CLINICAL PRACTICE
PellikkaPatricia A. Pellikka, M.D., Mayo Clinic College of Medicine and Mayo Foundation, Rochester, MN, USA

Technologic advances have resulted in miniaturization of ultrasound systems. Battery-operated, hand-held cardiac ultrasound devices (HHCU) devices weigh less than one pound, fit into the pocket of a laboratory coat, and have been approved by the FDA for cardiac imaging. MORE»

 

LEFT VENTRICULAR FUNCTION IN PATIENTS WITH CHRONIC TOTAL OCCULSION OF LAD: LONG-TERM FOLLOW-UP
Prokudina
Maria Prokudina, M.D., Ph.D., Federal Center of Heart, Blood and Endocrinology, St. Petersburg, Russia

There is no agreement regarding the revascularization of patients with chronic total occlusions of left descending artery and signs of ischemia. One of the treatment goals is improvement of left ventricle function. MORE»


MECHANISMS OF HYPERTROPHY IN VALVULAR HEART DISEASE
OlsenNiels T. Olsen, M.D., Ph.D., Rigshospitalet, Copenhagen, Denmark

Myocardial hypertrophy has a prominent role in valvular heart disease. The evaluation of hypertrophy is invaluable when determining the hemodynamic significance of a valve lesion, as the myocardium responds to increased load from regurgitant or stenotic valve lesions with growth in predictable patterns. MORE»

 

ATORVASTATIN ATTENUATES ATHEROSCLEROSIS IN THE VALVES AND FEMURS FROM HYPERCHOLESTEROLEMIC LDLR-/- MICE AS=OP Rajamannan
Nalini M. Rajamannan, M.D., Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Atherosclerosis and osteoporosis are the leading causes of morbidity and mortality in the aging population in the Unites States. Evidence indicates that hyperlipidemia plays a paradoxical role in these disease processes. MORE»

 

ATYPICAL AND UNUSUAL CLINICAL PRESENTATIONS OF PATIENTS WITH ISCHEMIC HEART DISEASE Reddy
Hanumanth K. Reddy, M.D., St. Louis University Medical School, St. Louis, Missouri, USA

Ischemic heart disease is the leading cause of death worldwide accounting for 7 million deaths annually. Chest pain is the cardinal symptom in patients with ischemic heart disease (IHD). MORE»

 

TRANSLATION OF HDL FUNCTIONALITY INTO CLINICAL PRACTICE
Rosenson
Robert S. Rosenson, M.D., School of Medicine at Mount Sinai, New York, NY, USA

HDL is conventionally quantified by the cholesterol cargo transported in these protein rich lipoprotein particles. In prospective population studies and clinical trials with low to moderate intensity statins, HDL cholesterol is biomarker of atherosclerotic cardiovascular disease risk. MORE»

 

 

DEVICE CLOSURE OF COMPLEX ATRIAL SEPTAL DEFECT IN ADULTS- ISSUES AND SOLUTIONS
Sadiq
Masood Sadiq, M.D., The Children's Hospital/The Institute of Child Health, Lahore. Pakistan

A complex ASD is defined as presence of a large- >20mm (stretched diameter = 26 mm) ASD associated with a deficient (= 4 mm) rim located at the anterior, inferior, or posterior portion of the atrial septum, two separate ASDs within the atrial septum (distant or close to each other); and multi-fenestrated septum, defects associated with a floppy, redundant, and hyper mobile atrial septum (excursion = 10 mm), considered to be aneurysmal, irrespective of their size. MORE»

 

BENEFIT AND RISKS OF ANTIDIABETIC TREATMENT IN PATIENTS WITH CORONARY ARTERY DISEASE AND HEART FAILURE
Saely
Christoph H. Saely, M.D., VIVIT Institute, Academic Teaching Hospital, Feldkirch, Austria

Diabetes mellitus is a paramount risk factor both for coronary artery disease (CAD) and heart failure, and the prevalence of diabetes among patients with CAD or heart failure is high. While better glucose control epidemiologically is associated with a lower incidence of cardiovascular events, lowering blood glucose failed to lower the incidence of macrovascular diabetes complications, i.e. of atherosclerotic cardiovascular disease in multiple trials, in particular among patients with established CAD. MORE»

 

 

PHARMACOLOGICAL MODULATION OF ANGIOTENSIN-II-INDUCED ARTERIAL MONONUCLEAR CELL ADHESION BY NUCLEAR RECEPTORS ACTIVATION
Sanz
Maria J. Sanz, Ph.D., Institute of Health Research INCLIVA, Valencia, Spain

The need of effective strategies to treat and prevent atherosclerosis led us to investigate the effect of combined concentrations of Rosuvastatin and bexarotene on angiotensin II-induced arterial mononuclear cell recruitment. MORE»

 

 

ROLE OF MINOCYCLINE IN MYOCARDIAL ISCHEMIA-REPERFUSION INJURY: AN OLD DRUG WITH NEW IMPLICATIONS
Scarabelli
Tiziano M. Scarabelli, M.D., Ph.D., St John Hospital & Medical Center/Wayne State University SOM, USA

Minocycline is a semisynthetic second -generation tetracycline with proven safety, which is used in humans for the treatment of acne and urethritis. The drug is also considered for the treatment of severe chronic inflammatory diseases, such as rheumatoid arthritis, as it exerts anti-inflammatory effects that are completely separate and distinct from its antimicrobial action. MORE»

 

HIGH SENSITIVITY CARDIAC TROPONIN – A CARDIOLOGIST'S FRIEND OR FOE?
Schaefer
Saul Schaefer, M.D., University of California, Davis, CA, USA

Cardiac troponin I and T (cTnI and cTnT) are components of the cardiac myocyte myofibrillar apparatus that are released when these cells are injured. Current assays set “normal” at levels that incorporate 99% of the non-diseased population, with usual upper limits in the range of 0.05ug/ml. Troponin elevations are useful in diagnosing acute coronary syndrome (ACS) in conjunction with clinical, electrocardiographic, and imaging data. MORE»

 

 

NEW TECHNOLOGIES TO IMPROVE CRT OUTCOME
Seidl
Karlheinz Seidl, M.D., Klinikum Ingolstadt, Germany

CRT has evolved as an established treatment for advanced heart failure symptoms, impaired LV function and intraventricular conduction delay despite substantial improvement in technology and optimization techniques 30% - 40% of pts fail to gain significant clinical benefit. What are the clinical challenges? MORE»

 

EVOLVING ROLE OF PLATELET FUNCTION TESTING IN ACUTE CORONARY SYNDROMES
Sharma
Rakesh K. Sharma, M.D., University of Arkansas Medical Science, Little Rock, AR, USA

The substantial reduction in ischemic events provided by the dual anti-platelet regimen with aspirin and clopidogrel is extensively published in patients with acute coronary syndrome and patient’s undergoing percutaneous coronary intervention (PCI). MORE»

 

 

REGULATORY T CELLS IN ABDOMINAL AORTIC ANEURYSMS
Shi
Guo-Ping Shi, M.D., Brigham and Women's Hospital, Boston, MA, USA

Regulator T cells (Tregs) are anti-inflammatory CD4+CD25+Foxp3+ T cells that are impaired in both numbers and activities in human and experimental coronary heart diseases. Abdominal aortic aneurysm (AAA) is an aortic disease that its pathogenesis involves extensive infiltration of pro-inflammatory cells that release pro-inflammatory cytokines to activate vascular cells and other inflammatory cells, thereby leading to arterial wall remodeling, expansion, and rupture. MORE»

 

IMAGING ACE AND ANGIOTENSIN RECEPTORS IN THE HEART
Shirani
Jamshid Shirani, M.D., St. Luke's Hospital and Health Network, Bethlehem, PA, USA

Angiotensin II (AII), an octapeptide member of the renin-angiotensin system (RAS), is formed by the enzyme angiotensin converting enzyme (ACE) and exerts adverse cellular effects through an interaction with its type 1 receptor (AT1R). MORE»

 

 

STABLE ISCHEMIC HEART DISEASE: EVOLVING CONCEPTSAND THE ROLE OF ISCHEMIA
Sidhu
Mandeep S. Sidhu, M.D., Albany Medical College, Albany, NY, USA

The optimal strategy for the management of patients with stable ischemic heart disease (SIHD) has been a matter of considerable debate over the past two decades. During this time period, there have been notable technologic evolutions in catheter-based revascularization that include the advent of bare metal and drug-eluting stents, the genesis of more effective antiplatelet therapy, the continued refinement of stent delivery platforms, improving operator experience and quality improvement initiatives which have led to declining complication rates. MORE»

IS THE DASH DIET THE OPTIMAL DIET FOR HEART FAILURE PATIENTS?
Silver
Marc A. Silver, M.D., Advocate Christ Medical Center, University of Illinois. IL, USA

Background: For symptomatic heart failure (HF) the major focus remains evidence based pharmacologics and devices. Little guideline evidence exists for nutritional support of HF patients beyond recommendations on limiting sodium excess. Endothelial dysfunction has been recognized as a pathophysiologic mechanism in the progression of HF. MORE»

 

 

TIME TO FOCUS ON CV HEALTH (NOT CV DISEASE)
Sperling
Laurence S. Sperling, M.D., Emory University School of Medicine, Atlanta, GA, USA

Despite rapidly advancing technologies in the treatment of CV diseases the current status of healthcare economics and global epidemiologic trends related to non-communicable diseases are unsustainable. A healthcare transformation is needed with a greater focus on CV health promotion and disease prevention. MORE»

 

ROLE OF ENDOTHELIN-1 AND CAMKINASE II SIGNALING IN CARDIOVASCULAR COMPLICATIONS
Srivastava
Ashok K. Srivastava, Ph.D., CRCHUM, University of Montreal, Montreal, Quebec, Canada

Vasoactive peptides such as angiotensin II and endothelin-1 as well as growth factors regulate vascular homeostasis through signaling pathways that are triggered in both normal and disease states. These vasoactive peptides and growth factors also increase the cellular levels of calcium which, through calcium binding effector systems initiates the downstream signaling and physiological responses in target cells. MORE»

 

ABLATION OF IDIOPATHIC VENTRICULAR TACHYCARDIA
Srivathsan
Komandoor S. Srivathsan, M.D., Mayo Clinic, Arizona, USA

Idiopathic ventricular tachycardia occurs when ventricular tachycardia occurs in the absence of detectable heart disease. Other than syncope they can cause cardiomyopathy if Premature Ventricular Contraction is frequent. MORE»

 

VASCULAR HEALING & BIORESORBABLE SCAFFOLDS: FROM PLATELETS, LEUKOCYTES TO ENDOTHELIAL CELLS
Tanguay
Jean-Francois Tanguay, M.D., Université de Montréal, Canada

Vascular endothelium damage occurs in acute situations such as following percutaneous coronary intervention or spontaneously plaque rupture. Tissue damages can also result from chronic conditions linked to cardiovascular risk factors such as diabetes, dyslipidemia and hypertension, which induce a sustained pro-inflammatory status and impair vascular endothelial cell functions. MORE»

 

OLD AND EMERGING OPTIONS FOR TREATMENT OF REFRACTORY ANGINA: A CRITICAL APPRAISAL
Thadani
Udho Thadani, M.D., University of Oklahoma Health Sciences Center and VA Medical Center, Oklahoma City, OK, USA

Patients with refractory angina are considered to be not suitable candidates for a revascularization procedure, and remain symptomatic despite good medical therapy. However, some patients with refractory angina, experience a marked symptomatic relief after adjustment of their antianginal drugs and lifestyle modifications, including regular exercise. MORE»

MOLECULAR TARGETING OF DILATED CARDIOMYOPATHY
Tuana
Balwant S. Tuana, Ph.D., University of Ottawa Heart Institute, Ottawa, Canada

The E2F/Pocket protein pathway regulates cardiac growth, differentiation, and death. Modulating its activity presents intriguing possibilities for targeting cardiac disease. E2F activation leads to hypertrophy and apoptosis. MORE»

 

 

MITOCHONDRIAL DIVISION/MITOPHAGY INHIBITOR (MDIVI) AMELIORATES PRESSURE OVERLOAD INDUCED HEART FAILURE
Tyagi
Suresh C. Tyagi, Ph.D., University of Louisville School of Medicine, Louisville, KY, USA

We have previously reported the role of anti-angiogenic factors in inducing the transition from compensatory cardiac hypertrophy to heart failure and the significance of MMP-9 and TIMP-3 in promoting this process during pressure overload hemodynamic stress. MORE»

IMATINIB: A NOVEL CANDIDATE FOR TREATMENT OF PERMEABILITY EDEMA
van Nieuw Amerongen
Geerten P. van Nieuw Amerongen, Ph.D., VU University Medical Center, Amsterdam, The Netherlands

Endothelial hyperpermeability and vascular leakage are significant pathogenic phenomena. Although contributing to life-threatening conditions like acute respiratory distress syndrome, they currently lack specific therapy. In a case-report we reported fast resolution of pulmonary edema upon treatment with the tyrosine kinase inhibitor imatinib. MORE»

 

 

PERICUTANEOUS HEMODYNAMIC SUPPORT FOR HIGH RISK PCI: INDICATIONS AND RESULTS
Vetrovec
George W. Vetrovec, M.D., VCU Medical Center Richmond, VA, USA

Hemodynamic support has a limited but very specific and important role in the management of myocardial ischemia in the cardiac catheterization lab. Indications for its use include (1) cardiogenic shock, particularly in the setting of Acute Myocardial Infarction in which case the immediate support provides the time and hemodynamic stability to complete revascularization. MORE»

 

GENDER DISPARITY IN CORONARY HEART DISEASE: BIAS, BIOLOGY, OR BOTH?
Wenger
Nanette K. Wenger, M.D., Emory University School of Medicine, Atlanta, GA, USA

Cardiovascular disease remains a major cause of mortality for women both in industrialized economies and in developing nations. A stunning improvement has occurred in cardiovascular disease mortality for U.S. women between 2000 and 2010, attributable both to application of evidence-based therapies of established cardiovascular disease and to preventive interventions; these likely derived from research studies of cardiovascular disease in women. MORE»

 

NEW GUIDELINES ON CARDIOVASCULAR RISK ASSESSMENT
Wong
Nathan D. Wong, Ph.D., University of California, Irvine, CA, USA

The Framingham Heart Study first noted that risk functions for predicting cardiovascular disease (CVD) risk provide an efficient way for identifying persons at high risk who need preventive therapy; this led to future recommendations regarding the targeting of the intensity of therapy to a patient’s global risk. MORE»

 

IMPROVING ENERGY SUPPLY TO MEND A SICK HEART
Yang
Qinglin Yang, M.D., Ph.D., University of Alabama at Birmingham, Birmingham, AL, USA

Substrate supply to the heart plays an essential role in maintaining cardiac performance. Perturbations in energy metabolism have been linked to pathological cardiac hypertrophy and failure. However, our understanding of the regulation of substrate utilization in the adult heart remains poor. MORE»

 

 

CILIA AND CONGENITAL HEART DISEASE: WHAT IS THE CONNECTION?
Zahid
Maliha Zahid, M.D., Ph.D., University of Pittsburgh, Pittsburgh, PA, USA

Motile cilia at the embryonic node and in the respiratory tract are required for left-right patterning and for muco-ciliary clearance from the respiratory tract, respectively. The heart is one of the most asymmetric organs in the body in order to support two separate circulation systems, the pulmonary and systemic circulation, in parallel. MORE»

 

 

INTEGRATING NUTRITION EDUCATION INTO THE CARDIOVASCULAR CURRICULUM CHANGES MEDICAL STUDENT EATING HABITS
Zelis
Robert Zelis, M.D. Pennsylvania State University, Hershey Medical Center, Hershey, PA, USA

Background and Objective: Surveys of medical student curricula continue to demonstrate that nutrition education is not universally adequate. One measure of nutritional educational competence is a positive change in student eating habits. MORE»

DISCOVERY OF A NEW INDEX OF DUAL PATHWAY ATRIOVENTRICULAR NODE CONDUCTION
Zhang
Youhua Zhang, M.D., Ph.D., New York Institute of Technology (NYIT) College of Osteopathic Medicine, Old Westbury, NY, USA

Dual pathway atrioventricular (AV) node electrophysiology is the basis of AV nodal reentrant tachycardia (AVNRT). Current clinical criterion for dual pathway conduction is a discontinuity or “jump” in the AV conduction curve. MORE»

 

 

 

  CARDIOLOGY ONLINE NEWS

The Cardiology Online Journal
 Editor: Asher Kimchi, MD

Distinguished Cardiologists and Scientists Honored with 2016 International Academy of Cardiology Awards at the 21st World Congress on Heart Disease, Boston, MA, USA

2016 AwardsDr. Asher Kimchi, Founder and Chairman of the International Academy of Cardiology (IAC) announced the winning recipients of the 2016 IAC Awards at the 21st World Congress on Heart Disease held in Boston, MA, USA. In addition to the IAC awards, the committee also named three faculty to receive the Distinguished Fellowship Awards.

Dr. Asher Kimchi, together with Co-Chairmen Dr. Jeffrey S. Borer and Dr. John A. Elefteriades, headed a committee comprised of 225 of the world's leading cardiologists and scientists that reviewed a prestigious list of nominees and voted for their top choice.

The following awards for 2016 were presented at the Opening Ceremony of the International Academy of Cardiology Annual Scientific Sessions 2016, 21st World Congress on Heart Disease, to honor the memory of distinguished colleagues, all former members of the faculty of previous International Academy of Cardiology meetings who made major contributions to Medicine and Cardiology: MORE»


Dr. Eugene Braunwald to Deliver the 10th HJC Swan Memorial Lecture at the Opening Ceremony of the International Academy of Cardiology, Annual Scientific Sessions 2016, 21st World Congress on Heart Disease

Eugene BraunwaldAsher Kimchi, M.D., Founder and Chairman of the International Academy of Cardiology, announced that Eugene Braunwald, M.D., Distinguished Hersey Professor of Medicine at Harvard Medical School, and founding Chairman of the TIMI Study Group at the Brigham and Women’s Hospital, Boston, Massachusetts, USA, will deliver the tenth H.J.C. Swan Memorial Lecture at the Opening Ceremony of the International Academy of Cardiology, Annual Scientific Sessions 2016, 21st World Congress on Heart Disease, that will be held in Boston, MA, USA, from Saturday, July 30 through Monday, August 1, 2016.

Asher KimchiDr. Braunwald will present on the topic of “The War on Heart Failure”. Heart failure (HF) is a global problem with an estimated prevalence of 38 million patients worldwide, a number that is increasing with the ageing of the population. Despite some progress, the prognosis of HF is still worse than that of most cancers. Because of the seriousness of the condition, a declaration of war on HF is proposed on five fronts: 1) Efforts to treat HF by enhancing myofilament sensitivity to Ca²+; 2) Several abnormal Ca2+-handling proteins in the failing heart are candidates for gene therapy;
MORE»

 


Click here to view Cardiology Online News articles on Opening Lectures.

Click here to view more Cardiology Online News articles on Opening Ceremony of the IAC Annual Scientific Sessions and presentation of the IAC Awards.

 

Invited Speaker Presentations at the IAC Annual Scientific Sessions 2016, 21st World Congress on Heart Disease, Boston, MA, USA
(click on the photo to view the video)
 



 
21st WORLD CONGRESS ON HEART DISEASE

THE PRESENT AND FUTURE OF THE TOTAL ARTIFICIAL HEART
Arabia
Francisco Arabia, M.D., Cedars-Sinai Medical Center, Los Angeles, CA, USA

We aim to better understand the pt population with biventricular failure receiving TAH as a BTT, determine outcomes in 3 eras, effect of implanting ctr on outcomes, and adverse events related to this therapy. MORE»
 

2016 UPDATE ON TREATMENT OF HYPERTENSION
Aronow
Wilbert S. Aronow, M.D., Westchester Medical Center/New York Medical College, Valhalla, NY, USA

Numerous guidelines from 2011 through 2015 except for JNC 8 recommended that the blood pressure (BP) goal should be <140/90 mm Hg in persons younger than 80 years and <150 mm Hg in persons 80 years and older. JNC 8 recommended that the BP goal should be <150/90 mm Hg in persons 60 years and older without diabetes or chronic kidney disease. MORE»

 

DELIRIUM IN THE INTENSIVE CARE UNIT: MORE THAN A NUISANCE
Barness
Gregory W. Barsness, M.D., Mayo Clinic, Rochester, MN, USA

Regardless of the underlying condition and comorbidities, along with pain and agitation, delirium is a common condition with major impact on the care and outcome of patients requiring intensive care unit (ICU) hospitalization. MORE»

 

ACELLULAR BIOLOGICS FOR CARDIAC REGENERATION
Behfar
Atta Behfar, Ph.D., Mayo Clinic, Rochester, MN, USA

The global drive to generate new curative therapies is fueled by a growing unmet perpetuated by the heart failure pandemic. Regenerative trials in cardiovascular disease have focused on the use of cell-based therapy in acute myocardial injury, in order to halt progression towards heart failure, or in congestive heart failure, to regenerate a deteriorating myocardium. MORE»

PET AND CT ASSESSMENT OF CORONARY FLOW PHYSIOLOGY
Berman
Daniel S. Berman, M.D., Cedars-Sinai, Los Angeles, California USA

Assessment of fractional flow reserve (FFR) and coronary flow reserve by invasive coronary angiography provide physiologic assessments that complement the anatomic assessment of coronary stenosis for guiding patient management of patients with coronary artery disease. MORE»

 

CONTROVERSIES IN ANTIPLATELET AND ANTICOAGULANT THERAPY
Bhatt
Deepak L. Bhatt, M.D., Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

Antiplatelet therapy is critical for patients with acute coronary syndromes, those undergoing coronary stenting, and especially for patients with both indications. Aspirin continues to be the backbone of antiplatelet strategies in cardiovascular secondary prevention. MORE»

PLAQUE LYMPHANGIOGENESIS: TO DRAIN OR NOT TO DRAIN
Biessen
Erik A. L. Biessen, Ph.D., Maastricht University, Maastricht, Netherlands

Vulnerable plaques are hallmarked by more pronounced inflammation and neoangiogenesis. Although angiogenesis and lymphangiogenesis are driven by partly overlapping cues, and especially under inflammatory conditions go hand in hand, plaque lymphangiogenesis only in one single earlier report been linked to plaque stability. MORE»

TICAGRELOR AND STATIN HAVE SYNERGISTIC EFFECTS ON MYOCARDIAL PROTECTION AGAINSY ISCHEMIA-REPERFUSION INJURY
Birnbaum
Yochai Birnbaum, M.D., Baylor College of Medicine, Houston, TX, USA

In addition to P2Y12 receptor antagonism, ticagrelor (TIC) inhibits the equilibrative- nucleoside-transporter-1 and thereby, adenosine cell re-uptake. Prior data show that TIC limits infarct size in non-diabetic rats and that the effect is adenosine dependent. MORE»

PREVENTION OF SUDDEN CARDIAC DEATH: CHALLENGES AND OPPORTUNITIES
Cain
Michael Cain, M.D., University at Buffalo, Buffalo, NY, USA

Strategies for prevention of sudden cardiac death in the setting of coronary artery disease rely on implantable cardiac defibrillators (ICD) in a subset of patients with left ventricular ejection fractions <35%. Many ICDs are implanted needlessly. MORE»


EXERCISE RELATED HYPERTENSION (ERH) MAY NOT BE A BENIGN PHENOMENON
Charuzi
Yzhar Charuzi, M.D., Cedars Sinai Medical Center, LA, USA

Blood Pressure (BP) increases with exercise. However a Systolic BP reaching or exceeding 200mm Hg is considered pathological. We recently observed a 78 years old male who, while walking uphill suddenly noticed loss of speech. MORE»

PREVENTION AND INTERFERENCE OF ATHEROSCLEROTIC HEART DISEASE IN MULTIPLE ANIMAL MODELS
Chatterjee
Subroto Chatterjee, Ph.D., Johns Hopkins University, Baltimore, MD, USA

We previously observed that the level of cholesterol and glycosphingolipids (GSL) rise and fall in tandem upon plasma exchange therapy in patients with LDL receptor negative homozygous familail hypercholesterolemia. MORE»

BIOMARKERS OF THE FUTURE: METABOLOMIC PREDICTORS OF CARDIOMETABOLIC DISEASE
Cheng
Susan Cheng, M.D., Brigham and Women's Hospital, Boston, MA, USA

By providing information on the diversity of small molecule metabolites in biological systems, current era metabolomics now offer the potential to comprehensively integrate data on both the intrinsic and extrinsic exposures that contribute to complex diseases such as cardiovascular disease. MORE»

RISK STRATIFICATION AND THERAPY OF ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY
Corrado
Domenico Corrado, M.D., Ph.D., University of Padova, Italy

Arrhythmogenic Right Ventricular Cardiomyopathy is a genetically determined cardiomyopathy which predisposes to life-threatening ventricular arrhythmias and arrhythmic cardiac arrest. The main goal of clinical management is prevention of sudden cardiac death. MORE»

IMPROVEMENT IN CLINICAL OUTCOMES WITH BIVENTRICULAR VERSUS RIGHT VENTRICULAR PACING IN THE BLOCK HF STUDY
Curtis
Anne B. Curtis, M.D., University of Buffalo, Buffalo, NY, USA

Sustained right ventricular (RV) apical pacing may lead to deterioration in ventricular function and an increased risk of heart failure, especially in patients with pre-existing systolic dysfunction. MORE»

SHORT AND LONG NON-CODING RNAs AS BIOMARKERS OF ACUTE CARDIAC CONDITIONS
Devaux
Yvan Devaux, Ph.D., Luxembourg Institute of Health, Luxembourg

The first draft of the human genome was published in 2001. However, it is only 10 years later that the ENCODE Int'l Consortium revealed that, while more than 80% of the human genome is transcribed into RNAs, only less than 2% of these RNAs are subsequently translated into proteins. MORE»


PATHOGENESIS AND THERAPY OF DIABETIC CARDIOMYOPATHY
Dhalla
Naranjan S. Dhalla, Ph.D., M.D. (Hon.), St. Boniface Hospital Albrechtsen Research Centre, University of Manitoba, Winnipeg, MB, Canada

Chronic diabetes is known to be associated with the development of cardiomyopathy, metabolic derangement and cardiac dysfunction. Extensive studies in our laboratory have revealed that cardiac dysfunction due to chronic diabetes is associated with marked alterations in subcellular organelles such as myofibrils, sarcoplasmic reticulum and sarcolemma. MORE»

CARDIAC IMAGING FOR EVALUATION OF CORONARY ARTERY DISEASE IN PATIENTS WITH HYPERTENSION
Elhendy
Abdou Elhendy, M.D., Ph.D., Marshfield Clinic, Marshfield, WI, USA

Hypertension is a major risk factor for coronary artery disease (CAD) and related morbidity. Identification of an accurate non-invasive method for diagnosis of CAD is important to plan therapeutic and interventional management in order to improve outcome. MORE»

HIGH-SENSITIVITY ASSAY FOR CARDIAC TROPONIN: NOVEL TOOLS FOR RISK PREDICTION IN AMBULATORY PATIENTS
Everett
Brendan M. Everett, M.D., Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Assays for cardiac troponin have become increasingly sensitive, and are now able to detect very low concentrations of circulating cardiac troponin in a substantial proportion of stable patients who are not suspected of having myocardial infarction. MORE»

CpG DNA REGULATION OF COAGULATION: IMPLICATIONS FOR ACUTE CORONARY ARTERY DISEASE
Filep
Janos G. Filep, M.D., University of Montreal, Montreal, Quebec, Canada

Bacteraemia is associated with increased risk of acute coronary artery disease and stroke. Bacterial DNA and mitochondrial DNA, containing unmethylated CpG dinucleotide motifs are potent inducers of immune responses during infection MORE»


HYPERTENSION UPDATE: QUO VADIMUS?
Galis
Zorina S. Galis, Ph.D., Vascular Biology and Hypertension, National Heart Lung and Blood Institute, Bethesda, MD, USA

Hypertension continues to represent a formidable challenge to human health and to healthcare worldwide. Exciting new developments in clinical and fundamental hypertension research are poised to change how we understand and approach the clinical management of hypertension. MORE»

COMPUTED TOMOGRAPHY ANGIOGRAPHY VS. CORONARY ANGIOGRAPHY: A 3D VESSEL FEATURE COMPARISON AND VALIDATION
Garcia
Joel Garcia, M.D., Orlando Health, Orlando, FL, USA

Differences in vessel features between computed tomography angiograms (CTA) and coronary angiograms have not been rigorously studied, therefore we sought to validate CTA 3-dimensional (3D) vessel data against coronary angiography MORE»


ROLE OF ECHOCARDIOGRAPHY IN EPIDEMIOLOGIC STUDIES AND CLINICAL TRIALS: AN HISTORICAL PERSPECTIVE
Gardin
Julius M. Gardin, M.D., Hackensack University Medical Center, Rutgers New Jersey Medical School, NJ, USA

Non-invasive transthoracic echocardiography (TTE) for assessment of subclinical and clinical heart disease – initially, left ventricular (LV) mass, geometry and function – dates from the 1980’s. In parallel, TTE successfully demonstrated in hypertensive patients reduced LV mass and improved outcomes MORE»

THYROID HORMONE TREATMENT OF HEART FAILURE: IS THERE A THERAPEUTIC WINDOW?
Gerdes
A. Martin Gerdes, Ph.D., New York Institute of Technology – College of Osteopathic Medicine, Old Westbury, NY, USA

In 1950, a study showed that Thyroid Hormone (TH) treatment significantly reduced cardiovascular mortality and rates of myocardial infarction in three patient groups. Rather than extend these findings, subsequent poorly designed larger clinical studies using toxic doses of TH analogs MORE»

THE CENTRAL ROLE OF SMOOTH MUSCLE CELL MITOCHONDRIA IN THE PREVENTION OF ABDOMINAL AORTIC ANEURYSM BY LOW LEVEL LASER THERAPY
Gertz
S. David Gertz, M.D., Ph.D., The Hebrew University of Jerusalem and Hadassah University Hospital, Jerusalem, Israel

We showed, by high frequency ultrasound, that phototherapy with low-level laser, a non-thermal, near-infrared radiation, used widely for reduction of pain and acceleration of wound healing, prevents de novo formation and progression of pre-existing abdominal aortic aneurysm MORE»

UPDATE ON ASPIRIN IN THE PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE
Hennekens
Charles H. Hennekens, M.D., Dr.P.H., Florida Atlantic University, Boca Raton, FL, USA

In secondary prevention among a wide range of patients who have survived a prior occlusive vascular event, as well as during acute myocardial infarction and acute occlusive stroke the absolute reductions far exceed the absolute risks. In primary prevention, tbe balance is less clear. MORE»


IMPACT OF EXERCISE CAPACITY FOR RIGHT AND LEFT HEART FAILURE
Hirashiki
Akihiro Hirashiki, M.D., Nagoya University School of Medicine, Nagoya, Japan

Cardiopulmonary exercise testing is a diagnostic tool used to detect serial changes in exercise capacity, and it is of particular benefit for patients with chronic heart failure to assess peak oxygen uptake (peak VO2) and minute ventilation/carbon dioxide production (VE/VCO2) slope. MORE»

ATRIAL FUNCTIONAL MITRAL REGURGITATION: THE LEFT ATRIUM GETS ITS DUE RESPECT
Hoit
Brian D. Hoit, M.D., University Hospitals Case Medical Center, Case Western Reserve University. Cleveland, OH, USA

Moderate or greater mitral regurgitation (MR) is the most frequent valve disease in the United States. Competence of the mitral valve requires the temporally and spatially coordinated interaction of the mitral leaflets with the annulus, chordae tendinae, and papillary muscles; MORE»

INITIAL STAGES OF OBESITY ARE ASSOCIATED WITH INCREASED CARDIOVASCULAR ACTIVATION UNDER STRESS
Jezova
Daniella Jezova, M.D., Slovak Academy of Sciences, Bratislava, Slovakia

Stress and obesity are well known risk factors for cardiovascular diseases. The recognition of early markers of cardiovascular risk during the development of obesity is essential. The hypothesis tested was that under stress conditions subjects at initial stages of obesity MORE»

ATRIAL FUNCTIONAL MITRAL REGURGITATION: MACROPHAGE DEPOSITION OF CHOLESTEROL INTO THE EXTRACELLULAR MATRIX - A PATHWAY FOR REVERSE CHOLESTEROL TRANSPORT
Jin
Xueting Jin, M.D., National Institutes of Health, Bethesda, Maryland, USA

To investigate the potential for mobilization of extracellular cholesterol within atherosclerotic plaques. Background: Atherosclerotic plaques develop as a result of an imbalance between cholesterol accumulation and cholesterol removal. MORE»

THE BENEFITS AND RISKS OF LEFT VENTRICULAR ASSIST DEVICE IMPLANTATION; WHERE IS THE POINT OF CLINICAL EQUIPOISE?
Johnson
Maryl R. Johnson, M.D., University of Wisconsin, Madison, WI, USA

Left ventricular assist devices (LVADs) are used to treat patients with severe heart failure, both as a bridge to transplantation and as destination therapy. However, the best time to proceed with LVAD implantation remains to be determined. MORE»

AGING AND HEART FAILURE 2016. UPDATE
Jugdutt
Bodh I. Jugdutt, M.D., University of Alberta, Edmonton, Alberta, Canada

Concurrent worldwide increases in the aging population and prevalence of heart failure (HF) are accompanied by a parallel increase in the elderly (age = 65 years) with two leading causes of HF, hypertension and myocardial infarction. MORE»

TRANSITION TO STAGE D HEART FAILURE AMONG STABLE OUTPATIENTS WITH SYSTOLIC HEART FAILURE
Kalogeropoulos
Andreas P. Kalogeropoulos, M.D., Ph.D., Emory University, Atlanta, GA, USA

Incidence rates and risk factors for transition to Stage D heart failure (HF) among patients with stable, Stage C HF with reduced ejection fraction have not been described. Methods: We evaluated 3-year transition rates to clinically determined Stage D HF, after accounting for competing mortality, in 919 outpatients MORE»

TRANSULNAR INTERVENTIONS
Kaluski
Edo Kaluski, M.D., Guthrie Health System, PA, USA

The use of transradial access for diagnostic and therapeutic interventions has dramatically increased in the recent years and has become the preferred approach for coronary angiography and intervention. The ulnar artery is similar in diameter however is somewhat deeper MORE»

THE ROLE OF ECHOCARDIOGRAPHY IN THE MANAGEMENT OF PATIENTS UNDERGOING VENTRICULAR ASSIST DEVICE IMPLANTATION AND/OR TRANSPLANT SURGERY
Kato
Tomoko S. Kato, M.D., Ph.D. , Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan

Heart transplantation (HTx) is a curative treatment for patients with advanced heart failure; however, since transplant opportunity is severely limited due to donor shortage, left ventricular assist device has evolved into a standard therapy for patients awaiting HTx. MORE»

TREATING FLUID OVERLOAD WITH FLUID; ROLE OF PERITONEAL DIALYSIS IN MANAGEMENT OF HEART FAILURE
Kazory
Amir Kazory, M.D., University of Florida, Gainesville, Florida, USA

Heart failure (HF) remains the most common reason for hospital admission in older patients resulting in significant burden on healthcare expenditure. The currently available therapeutic modalities for HF do not seem yet to be producing optimal results. MORE»

THE USE OF POINT OF CARE ULTRASOUND TO GUIDE MANAGEMENT IN HEART FAILURE
Kedan
Ilan Kedan, M.D.
, Cedars Sinai Heart Institute, Beverly Hills, CA, USA

Point of Care ultrasound has long been used in the acute care and emergency setting for management of trauma patients. MORE»

EDUCATION AND MORTALITY: IS A COLLEGE DEGREE UNIVERSALLY PROTECTIVE?
Klatsky
Arthur L. Klatsky, M.D., Kaiser Permanente Division of Research, Oakland, CA, USA

To study risk of death in relation to educational attainment in 273,843 persons. Background: Low socio-economic status has been associated with increased incidence of many medical conditions and connected to racial and ethnic health disparities. MORE»

EFFECT OF ENDOTHELIAL CELL SENESCENCE ON THE HEAT SHOCK RESPONSE AND CELLULAR FUNCTION
Knowlton
Anne. A. Knowlton, M.D., Sacramento VA Medical Center, Mather, CA USA and University of California, Davis, CA, USA

Increasing evidence supports that replicative senescence, cessation of cell division, plays a role in the progression of the aging phenotype. With cellular senescence, cells undergo morphologic, physiologic and functional changes. MORE»

DOES CYSTATIN SN INFLUENCE ON CYSTATIN C LEVEL IN ISCHEMIA AND PREVIOUS MYOCARDIAL INFARCTION?
Korolenko
Tatiana A. Korolenko, Ph.D., Institute Physiol. Fund. Med., Novosibirsk, Russia

Objectives: To investigate whether patients with ischemic heart disease and previous myocardial infarction (MI) display altered serum cystatin C/cystatin SN ratio. MORE»

CURRENT STATUS OF INTRAVASCULAR IMAGING
Koshy
Santhosh K.G. Koshy, M.D., University of Tennessee Health Sciences Center, Memphis TN, USA

Diagnostic angiography has been the mainstay of confirmatory diagnosis of vascular atherosclerosis. Being a luminogram its ability to determine the presence and extent of atherosclerosis is limited by changes in the vessel wall that is adjacent to the atherosclerotic plaque. MORE»

ROLE OF CVD RISK ASSESSMENT IN COPD
Lee
Hwa Mu Lee, M.D., University of California, Irvine, Irvine, CA, USA

Chronic obstructive pulmonary disease is commonly associated with cardiovascular disease since they are both linked with shared factors such as age and smoking history; however, in clinical practice, these two diseases are treated separately. MORE»


DECIPHERING THE ROLE OF MITOPHAGY IN THE HEART DURING FASTING
Liang
Qiangrong Liang, M.D., Ph.D., New York Institute of Technology – College of Osteopathic Medicine, Old Westbury, NY, USA

Alternate-day fasting or starvation is beneficial to the heart, but the underlying mechanism remains speculative. Starvation activates general autophagy, which may contribute to the cardioprotective effect of fasting. MORE»

AVOIDING AND SOLVING COMPLICATIONS DURING PERCUTANEOUS CLOSURE OF ASD
Lorber
Avraham Lorber, M.D., Rambam Medical Campus, Haifa, Israel

We present 11 cases of percutaneous transcatheter occlusion of atrial septal defects in adults. These select cases represent an educational approach to special dilemmas, complications, and challenges MORE»

GLYCOSAMINOGLYCANS (GAGS) IN CARDIOVASCULAR DISEASE: SEARCHING FOR THE SWEET SPOT
Lucas
Alexandra R. Lucas, M.D., University of Florida, Gainesville, FL, USA

The endothelial glycocalyx alters immune reactions. Among other functions, glycosaminoglycans in the glycocalyx bind chemokines that attract immune cell invasion. MORE»

TRANSLATING VASCULAR BIOLOGY INTO CLINICAL CARE FOR CARDIOLOGY
Maiese
Kenneth Maiese, M.D., Rutgers University of Medicine & Dentistry of New Jersey

With the progressing aging of the world’s population, cardiovascular disease will continue to significantly impact millions of individuals throughout the globe. This disorder remains one of five leading causes of death that are cardiac disease, cancer, MORE»

A NANOMEDICAL APPROACH TO THE RESTORATION OF DYSFUNCTIONAL ENDOTHELIUM AND THE FUNCTION OF THE CARDIOVASCULAR SYSTEM
Malinski
Tadeusz Malinski, Ph.D., Ohio University, Athens, OH, USA

A dysfunctional endothelium is a common denominator in aging and several cardiovascular diseases: hypertension, diabetes, salt-induced hypertension and atherosclerosis. MORE»

 

CLINICAL GENETICS OF DILATED CARDIOMYOPATHY- TESTING WISELY
Marsh
James D. Marsh, M.D., University of Arkansas for Medical Sciences, Little Rock, AR, USA

Dilated cardiomyopathies (DCM) account for 10,000 deaths/year in the US; African-Americans have a 3-fold increased risk. There has been little solid information available on or the ability to make a precise genetic diagnosis in DCM. MORE»

WHAT HAPPENS TO THE BRAIN AFTER MYOCARDIAL INFARCTION?
Mehta
Jawahar L. Mehta, M.D., Ph.D. , University of Arkansas for Medical Sciences and VA Medical Center, Little Rock, AR, USA

It is assumed, but not proven, that acute myocardial infarction affects function of remote organs- such as kidneys and brain. We examined brain morphology in wild type (WT) mice subjected to left coronary artery (LCA) ligation. MORE»

OPTIONS FOR REMOTE PATIENT MONITORING IN THE LVAD POPULATION
Meyer
Dan M. Meyer, M.D., Methodist Health System, Dallas, Texas, USA

Multiple technologies are emerging that may have roles in remote patient monitoring in the LVAD population. These include smartphone applications and wearables, nanosensors, lab-on-a-chip platforms, and miniaturized systems. MORE»

SECONDARY PREVENTION OF CARDIOVASCULAR EVENTS
Mora
Samia Mora, M.D.
, Brigham and Women's Hospital, Boston, MA, USA

Cardiovascular risk among individuals with manifest cardiovascular disease remains high and has been termed “residual risk”. Results from a meta-analysis of statin trials involving 90,056 individuals found that the rate of a major vascular event MORE»

 

UPDATE ON CONTRAST REMOVAL FROM CORONARY SINUS DURING CORONARY ANGIOGRAPHY OR INTERVENTION FOR PREVENTION OF CONTRAST INDUCED NEPHROPATHY
Movahed
Mohammad-Reza Movahed, M.D., Ph.D., CareMore, Tucson, Arizona, University of Arizona College of Medicine, USA

Contrast usage during coronary angiography or intervention in patients with renal disease is associated with substantial risk of contrast induced nephropathy that can lead to higher mortality, longer hospital stay and substantial cost. MORE»
 

CAN GDF-15 BE USED AS A BIOMARKER IN DILATED CARDIOMYOPATHY
Nair
Nandini Nair, M.D., Ph.D., Texas Tech HSC, Lubbock, TX, USA

Growth and Differentiation Factor-15 (GDF-15) has been found to play an important role in fibrosis, inflammation and ventricular remodeling. The role of GDF-15 in regulation of cardiac remodeling in idiopathic dilated cardiomyopathy is less well-defined. MORE»

INNOVATIVE P-WAVE DETECTION FOR DISCRIMINATION BETWEEN VENTRICULAR AND SUPRAVENTRICULAR TACHYCARDIA IN SINGLE-CHAMBER ICDS: IS THE P-WAVE INVISIBLE DURING TACHYCARDIA?
Paydak
Hakan Paydak, M.D. , UAMS, Little Rock, AR, USA

Differentiation between supraventricular tachycardia and ventricular tachycardia remains a substantial clinical challenge in patients with single-chamber implantable cardioverter-defibrillators due to absence of visible P waves. MORE»

 

LOW GRADIENT SEVERE AORTIC STENOSIS: ECHO FEATURES AND CLINICAL SIGNIFICANCE
Pellikka
Patricia A. Pellikka, M.D., Mayo Clinic, Rochester, MN, USA

Current practice guidelines define severe aortic stenosis (AS) as aortic valve (AV) area less than1 cm2 and mean AV gradient greater than 40 mmHg. Low gradient severe AS refers to the condition of mismatch between an AV area which suggests severe AS and mean gradient MORE»

VALVE PROSTHESIS-PATIENT MISMATCH (VP-PM): A LONG-TERM PERSPECTIVE
Rahimtoola
Shahbudin H. Rahimtoola, M.D., University of Southern California, Los Angeles, CA, USA

VP- PM was first described in 1978 by Rahimtoola. From that time to 2011, aortic VP-PM has received a great deal of attention but studies have come to varying conclusions especially with regard to its effect on mortality. MORE»

 

 

OSTEOGENIC DIFFERENTIATION IS A MECHANISM FOR BIOPROSTHETIC VALVE CALCIFICATION
Rajamannan
Nalini M. Rajamannan, M.D., Mayo Clinic, Rochester, MN, USA

Bioprosthetic heart valve calcification is the major cause of structural valve deterioration (SVD). The mechanism of valve degeneration is unknown. This study hypothesizes that bioprosthetic valve calcification is a stem cell mediated bone differentiation process. MORE»

THE HIGHLY DIFFICULT LIPOPROTEIN: CONTROVERSIES AND NEW DIRECTIONS
Rosenson
Robert S. Rosenson, Ph.D., Icahn School of Medicine at Mount Sinai, New York, NY, USA

Classical epidemiology has established the incremental contribution of the high density lipoprotein (HDL) cholesterol measure in the assessment of atherosclerotic cardiovascular disease risk; however, genetic epidemiology does not support a causal relationship between HDL cholesterol and future risk of myocardial infarction. MORE»

CXCR6/CXCL16 AXIS IS INVOLVED IN MONONUCLEAR CELL ADHESION INDUCED BY ANGIOTENSIN II, POTENTIAL IMPLICATION IN ABDOMINAL AORTIC ANEURYSM (AAA) FORMATION?
Sanz
Maria J. Sanz, Ph.D., Faculty of Medicine, University of Valencia, Valencia, Spain

Abdominal aortic aneurysm is a degenerative disease of the aorta that mainly affects elderly population over the age of 65. Nowadays the pathways involved in its onset and progression remain unknown and angiotensin-II has been widely implicated. MORE»

CARDIOVASCULAR EFFECTS OF CARFILZOMIB, A NEW PROTEASOME INHIBITOR, ON CORONARY ARTERY RESISTANCE, VASCULAR TONE AND VASCULAR REACTIVITY
Scarabelli
Tiziano M. Scarabelli, M.D., The University of Alabama at Birmingham, Birmingham, AL, USA

Carfilzomib is a proteasome inhibitor which was recently approved in the United States as a single agent for the treatment of patients with relapsed and refractory Multiple Myeloma. Chemically it is a tetrapeptide epoxyketone and an analog of epoxomicin. MORE»


COMPARISON OF EARLY HEMODYNAMIC PERFORMANCE OF STENTED PERICARDIAL AND PORCINE AORTIC VALVES
Sharma
Rakesh K. Sharma, M.D., University of Utah, Salt Lake City, UT, USA

Data comparing the hemodynamic performance of stented pericardial and porcine aortic valves are conflicting. We performed a systematic review and meta-analysis comparing the early hemodynamic parameters of stented pericardial and porcine valves in patients undergoing isolated aortic valve replacement. MORE»

ASTHMA AS A RISK FACTOR OF HUMAN AND EXPERIMENTAL ABDOMINAL AORTIC ANEURYSM
Shi
Guo-Ping Shi, SC.D., D.SC., Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

Asthma and abdominal aortic aneurysms (AAA) both involve inflammation. It remains unknown whether these diseases interact. MORE»

THE CANCER ASSOCIATED FIBROBLAST AND THE HEART FAILURE ASSOCIATED FIBROBLAST- SIMILAR PHENOTYPE, SIMILAR PATHWAYS LEADING TO POTENTIALLY SIMILAR TREATMENT
Spinale
Francis G. Spinale, Ph.D., M.D., USC School of Medicine and WJB Dorn VA, Columbia, SC, USA

While morbidity, mortality, and health care costs associated with heart failure (HF) are increasing, advancements in early diagnosis and treatment strategies have not been forthcoming. Firstly, there is a need to differentiate HF phenotypes into different disease processes MORE»

RISK STRATIFICATION IN BRUGADA SYNDROME: ICD INDICATION IN PATIENTS WITHOUT HISTORY OF CARDIAC ARREST
Takagi
Masahiko Takagi, M.D., Ph.D., Osaka City Graduate School of Medicine, Osaka, Japan

Risk assessment in patients without previous documented VF or aborted sudden death (SCD) is not yet fully established. Indication for implantable cardioverter defibrillator in Brugada patients without documented VF or SCD is classified as Class II or III indication. MORE»

OPTIMUM TREATMENT OF ANGINA PECTORIS SHOULD TAKE INTO CONSIDERATION PATIENTS’ CIRCULATORY STATUS AND THE PRESENCE OF ASSOCIATED COMORBIDITIES IN THE YEAR 2016
Thadani
Udho Thadani, M.D., M.D., OU Medical Center and VA Medical Center, Oklahoma City, Oklahoma, USA

Currently many treatment options, including medicines, and revascularization procedures are available to treat patients with stable angina pectoris. All patients with angina pectoris due to underlying CAD should be treated with a low dose aspirin and a high dose, potent statin, if tolerated, MORE»

PREVENTION OF ACUTE MI BY AGGRESSIVE APPROACH TO TREAT UNSTABLE ANGINA
Ueda
Yasunori Ueda, M.D., Ph.D., Osaka National Hospital, Osaka, Japan

Although the incidence of in-hospital death from acute myocardial infarction (MI) is about 5%, about 40% of the patients who suffer acute MI die before hospitalization. MORE»


THE ROLE OF HEMODYNAMIC SUPPORT IN THE MANAGEMENT OF AMI WITH SHOCK
Vetrovec
George W. Vetrovec, M.D., VCU Medical Center Richmond, Virginia USA

Outcomes for Acute Myocardial Infarction have improved significantly with acute Percutaneous Coronary Intervention. However, the incidence of associated cardiogenic shock has increased and remains a major cause of death. MORE»

SEX DIFFERENCES IN THE CARDIOVASCULAR CONSEQUENCES OF DIABETES MELLITUS
Wenger
Nanette K. Wenger, M.D., Emory University School of Medicine, Atlanta, GA, USA

Cardiovascular disease is the leading cause of morbidity and mortality with type 2 diabetes mellitus, accounting for > 75% of hospitalizations and >5% of deaths. Women have a 3-fold excess of coronary heart disease risk compared to men MORE»

EFFICACY OF A CARDIOVASCULAR BEHAVIORAL INTERVENTION PROGRAM ON PROGRESSION OF ATHEROSCLEROSIS
Wong
Nathan D. Wong, Ph.D., University of California, Irvine, CA, USA

Limited data exist on the efficacy of multifactorial lifestyle programs on impacting the progression of atherosclerosis. We examined the efficacy of a lifestyle intervention program on progression of coronary artery calcium. MORE»

WHOLE HEART REGENERATION WITH HUMAN iPS CELL-DERIVED HEART PROGENITORS
Yang
Lei Yang, Ph.D., University of Pittsburgh, Pittsburgh, PA, USA

In US, about 50,000 people die each year due to the limited donor hearts for transplant. Thus the future treatment of heart disease requires the development of personalized therapeutic strategies, such as patient-specific cardiac tissues or whole bio-artificial hearts for transplantation. MORE»

 


 

 


 

Invited Speaker Presentations at the IAC Annual Scientific Sessions 2015, 20th World Congress on Heart Disease, Vancvouer, BC, Canada
(click on the photo to view the video)
 



 
20th WORLD CONGRESS ON HEART DISEASE

EVOLUTION IN THE MANAGEMENT OF LOW RISK PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT WITH CHEST PAIN
Amsterdam
Ezra A. Amsterdam, M.D., University of California (Davis) Medical Center, Sacramento, CA, USA

The majority of patients presenting to the ED with chest pain comprise a low risk population who do not have acute coronary syndrome (ACS) or other life threatening condition. Therefore, most at are low risk for morbidity and mortality. Such low risk patients are usually identified by absence of a history of cardiovascular disease, normal or nonischemic ECG, normal initial troponin, and clinical stability. MORE»
 

THE ROLE OF PHARMACOLOGICAL THERAPY IN CHRONIC HEART VALVE DISEASES
Borer
Jeffrey S. Borer, M.D., SUNY Downstate Medical Center, Brooklyn and New York, NY, USA

Valvular heart diseases (VHDs) are progressive. When they are “primary”, i.e., due to intrinsic abnormality of valve structure and not secondary to comorbid conditions (e.g., ischemia), they generally are characterized by long asymptomatic phases during which cardiac functional and hemodynamic debility progresses. Ultimately, these developments lead to symptoms, other morbidities and, finally, death. MORE»

 

 

THE 2014 AF GUIDELINES: WHAT'S NEW?
Cain
Michael E. Cain, M.D., University at Buffalo, Buffalo, NY, USA

The 2014 AHA/ACC/HRS Guidelines for the management of patients with atrial fibrillation (AF) are derived from published clinical trials, basic science, and comprehensive review articles. They supersede the ACC/AHA/ESC 2006 Guidelines and two subsequent focused updates from 2011. Key new recommendations impacting patient care are: MORE»

 

MANAGEMENT OF ASYMPTOMATIC AORTIC STENOSIS: WHAT IS NEW IN 2015?
Chaliki
Hari P. Chaliki, M.D., Mayo Clinic, Scottsdale, AZ, USA

Calcific aortic stenosis is now the primary etiology of aortic stenosis in the majority of patients. Risk factors such as hyperlipidemia play an important role in the progression of aortic stenosis. According to the most recent ACC/AHA guidelines, peak velocity greater than 4 m/sec, or a mean gradient of more than 40 mmHg and a valve area of less than 1.0 cm2 is considered hemodynamically severe aortic stenosis. MORE»

 

EVOLVING UNDERSTANDING OF STRESS CARDIOMYOPATHY
Chokslingam
Anand Chockalingam, M.D., Division of Cardiovascular Medicine, University of Missouri, Columbia, MO, USA

Stress cardiomyopathy (SC), also called Takotsubo cardiomyopathy, is increasingly diagnosed world over. ER physicians, Internists, Intensivists and anesthesiologists increasingly encounter SC patients presenting with angina, heart failure or arrhythmia. MORE»

 

 

LEFT VENTRICULAR REVERSE REMODELING WITH BIVENTRICULAR VERSUS RIGHT VENTRICULAR PACING IN PATIENTS WITH ATRIOVENTRICULAR BLOCK AND LEFT HEART FAILURE IN THE BLOCK HF TRIAL
Curtis
Anne Curtis, M.D., University at Buffalo, Buffalo, NY, USA

Background: In patients with heart failure (HF), biventricular pacing (BIV) attenuates adverse left ventricular (LV) remodeling in addition to improving survival and relieving symptoms. However, little is known about the effects of BIV pacing in HF patients with atrioventricular (AV) block. MORE»

CO2-ENRICHED WATER BATH AS A NOVEL THERAPY FOR PERIPHERAL VASCULAR DISEASE
Dhalla
Narajan Dhalla, Ph.D., M.D. Hon., ICS, St. Boniface Hospital Research, University of Manitoba, Canada

Peripheral artery disease (PAD) is a major health problem whereby narrowed arteries reduce blood flow to the ischemic limbs. We investigated the effects of CO2-enriched water bath (CEWB) therapy on blood flow in the ischemic hind limb. MORE»

WHOLE EXOME SEQUENCING FOR THORACIC AORTIC ANEURYSM: THE FUTURE IS HERE
Elefteriades
John A. Elefteriades, M.D., Yale University School of Medicine, New Haven, CT, USA

Background: Convincing evidence is accumulating that genetics play an important etiologic role in thoracic aortic aneurysm and dissection (TAAD). Multiple genes have been found to cause syndromic and familial TAAD. MORE»

A LARGE PRAGMATIC TRIAL OF STATINS IN PRIMARY PREVENTION: THE NEXT FRONTIER
Farkouh
Michael Farkouh, M.D., Cardiac Centre, University of Toronto, Toronto, Canada

Atherothrombotic disease is the most common cause of death in the world. Pharmacologic LDL lowering has been shown to reduce coronary heart disease (CHD) events according to the LDL level achieved with no demonstrated level below which events do not decrease with additional LDL lowering. Further, available data suggest that the earlier the LDL lowering occurs, the greater the therapeutic effect of a given decrease. MORE»


C-REACTIVE PROTEIN MODULATION OF INFLAMMATION IN ACUTE CORONARY ARTERY DISEASE
Filep
Janos G. Filep, M.D., University of Montreal, Montreal, QC, Canada

C-reactive protein (CRP) is an acute-phase reactant and an active regulator of innate immunity. Clinical studies have shown that elevated baseline serum CRP levels confer, albeit to varying degrees, additional prognostic value for future coronary artery disease (CAD) and death and may be useful for risk-guided therapy. CRP has been implicated in multiple aspects of atherogenesis and acute CAD; however, whether CRP plays a direct causal role in these events remains controversial. MORE»

THE SECRET SUPREMACY OF SMALL BLOOD VESSELS, AN ENDURING PUZZLE OF THE CARDIOVASCULAR SYSTEM: RESEARCH GAPS AND OPPORTUNITIES
Gallis
Zorina S. Gallis, Ph.D., National Heart, Lung, and Blood Institute, Bethesda, MD, USA

Small blood vessels are a critical component of the vascular system and essential for the maintenance and proper functioning of organs throughout the body. Their malfunction is a major contributor to local and systemic diseases. MORE»

SAFETY AND EFFICACY OF DUAL MOTION ROTATIONAL CORONARY ANGIOGRAPHY
Garcia
Joel A. Garcia, M.D., Orlando Health, Orlando, FL, USA

Background: Cardiac catheterization via standard angiography (SA) requires several angiograms while rotational coronary angiography (RA) employs the use of automated gantry acquisitions (LAO to RAO with a fixed cranial or caudal angulation) permitting complete visualization of the entire coronary tree via two injections of the left (LCA) (cranial and caudal) and one of the right coronary tree (RCA). MORE»

CARDIOPROTECTIVE EFFECTS OF THERAPEUTIC T3 TREATMENT IN MYOCARDIAL INFARCTION AND ISCHEMIA REPERFUSION
Gerdes
A. Martin Gerdes, Ph.D, Dept of Biomedical Sciences, New York Institute of Technology-College of Osteopathic Medicine, USA

Background: Myocardial Infarction (MI) leads to cardiac tissue hypothyroidism, a condition that by itself can lead to heart failure (HF). Potential improvements in LV remodeling and function with a therapeutic T3 dose after MI and ischemia/reperfusion (IR) are not clear. MORE»

WHAT DIABETES MELLITUS HAS TAUGHT US ABOUT POTENTIAL TREATMENTS FOR SMALL ABDOMINAL AORTIC ANEURYSMS
Gertz
S. David Gertz, M.D., Ph.D, The Hebrew University--Hadassah Medical School, Jerusalem, Israel

Increased detection of abdominal aortic aneurysm (AAA) at early stages of growth (more than 80% of those diagnosed now are less than 3.5 cm maximum diameter), and the high rate of severe complications of urgent, open abdomen or endovascular surgical treatment have emphasized the need for less invasive strategies that target the pathogenetic mechanisms of progression and rupture. MORE»

CARDIOVASCULAR RESPONSES TO THREATFUL CHALLENGES IN PERSONS WITH HIGH TRAIT ANXIETY
Jezova
Daniela Jezova, M.D., Slovak Academy of Sciences, Bratislava, Slovakia

An optimal cardiovascular response to threatening challenges is indispensable for coping with the situation. Anxiety disorders and high anxiety as a personality trait have been expected to be associated with autonomic lability and hyperreactivity during stress. MORE»


ADVANCED IMAGING FOR STRUCTURAL HEART DISEASE INTERVENTIONS
Jilaihawi
Hasan Jilaihawi, M.D., Cedars-Sinai Medical Center, Los Angeles, CA, USA

MORE»

BEYOND THE GUIDELINES - NEW OPTIONS FOR TREATING HEART FAILURE IN 2015
Johnson
Maryl R. Johnson, M.D., University of Wisconsin, Madison, Wisconsin, USA

The updated ACCF/AHA Guideline for the Management of Heart Failure is not even 2 years old, however, trials have suggested new potential treatment options for heart failure with reduced ejection fraction (HFrEF). Two of these trials will be reviewed. MORE»

ADJUDICATED VERSUS ADMINISTRATIVE HEART FAILURE WITH PRESERVED EJECTION FRACTION
Kalogeropoulos
Andreas Kalogeropoulos, M.D., Ph.D., Emory University, Atlanta, GA, USA

Heart failure (HF) with preserved ejection fraction (HFpEF) is associated with readmission and mortality rates similar to HF with reduced ejection fraction (HFrEF). No disease-modifying therapy for HFpEF exists to date, partially because of the multifactorial pathophysiology of HFpEF and the heterogeneity of patients. MORE»

POINT OF CARE ULTRASOUND, THE NEW PHYSICAL EXAMINATION
Kedan
Ilan Kedan, M.D., Cedars Sinai Heart Institute, Los Angeles, CA, USA

Background: Ultrasound technology has become a central part of modern day healthcare. Its use as a clinical tool will continue to expand as the technology becomes more portable. MORE»


HYBRID ATRIAL FIBRILLATION FOR ADVANCED ATRIAL FIBRILLATION
Khoynezhad
Ali Khoynezhad, M.D., Ph.D., Cedars-Sinai Medical Center, Los Angeles, CA, USA

Atrial fibrillation (AF) is the most common sustained arrhythmia and is associated with a nearly five-fold increased risk for stroke as well as over two-fold increased risk of death. For symptomatic drug-refractory AF, percutaneous ablation has been used with good success in paroxysmal AF. MORE»

BODY MASS INDEX AND MORTALITY IN A VERY LARGE COHORT: IS IT REALLY HEALTHIER TO BE OVERWEIGHT?
Klatsky
Arthur L. Klatsky, M.D., Northern CA Kaiser Permanente Division of Research, Oakland, CA, USA

Purpose: To study risk of death in relation to body mass index (BMI) in 273,843 free-living persons. Background: Despite substantial published literature controversy persists about the optimal level of body weight. MORE»


AGING, ESTROGEN, CELL SENESCENCE AND VASCULAR INFLAMMATION
Knowlton
Anne Knowlton, M.D., University of California, Davis, CA, USA

Aging is characterized by the development of systemic inflammatory changes, organ dysfunction and frailty. In females, loss of estrogen compounds these changes. MORE»

CURRENT STATUS OF INTRAVASCULAR IMAGING
Koshy
Santhosh Koshy, M.D., University of Tennessee Health Sciences Center, Memphis, Tennessee, USA

Currently available intravascular imaging techniques that are used in clinical practice, have major limitations related to resolution and ease of imaging. There have been major innovations in the field of imaging to improve on these limitations and to incorporate novel imaging techniques that venture beyond the traditional delineation of anatomical intravascular structures. MORE»

ALTERED NUCLEAR AND CYTOSKELETAL MECHANICS IN CARDIAC MYOCYTES WITH D192G NUCLEAR LAMIN MUTATION
Long
Carlin S. Long, M.D., University of Colorado, Denver, CO, USA

Atomic force microscopy whole-cell loading/unloading curves were used to study the mechanical behavior of cardiomyocytes carrying the LMNA D192G mutation which is known to cause a severe form of dilated cardiomyopathy. MORE»

COLCHICINE AND NEW MANAGEMENT STRATEGIES FOR ACUTE AND RECURRENT PERICARDITIS
Lopachuk
Gary D. Lopaschuk, Ph.D., University of Alberta, Edmonton, Alberta, Canada

In heart failure, changes in cardiac mitochondrial energy metabolism contribute to this contractile dysfunction and to a decrease in cardiac efficiency. The failing heart has defects in energy metabolic processes that compromise ATP production necessary to maintain contractile function. MORE»


ATHEROSCLEROSIS, CANCER AND WOUND HEALING; THE SYSTEMS BIOLOGY CONNECTION
Lucas
Alexandra R. Lucas, M.D., Department Medicine, Division Cardiology, University of Florida, USA

Serpins have critical regulatory roles in coagulation, inflammatory, and apoptosis, representing a large percentage of circulating proteins. Genetic serpin mutations cause severe disorders such as deficiency in alpha1 antitrypsin and neuroserpin or in sepsis with disseminated intravascular coagulation. MORE»

NAVIGATING THE COMPLEXITIES OF APOPTOSIS AND AUTOPHAGY IN CARDIOVASCULAR DISEASE: CAN WE CHART A CLEAR COURSE?
Maiese
Kenneth Maiese, M.D., University of Medicine & Dentistry of New Jersey, Newark, NJ, USA

The programmed cell death pathways of apoptosis and autophagy play a significant role in the reparative and regenerative processes of the cardiovascular system. Apoptosis can control tissue development and remodeling during the early stages of development. MORE»

EARLY DIAGNOSIS OF THE CARDIOVASCULAR SYSTEM - THE NANOMEDICAL EVALUATION OF ENDOTHELIAL DYSFUNCTION
Malinski
Tadeusz Malinski, M.D., Rudek Ohio University, Athens, Ohio, USA

Background: Endothelial dysfunction can be directly related to the dysfunction of the cardiovascular system. The dysfunctional endothelium is characterized, among others, by the deficiency of bioavailable nitric oxide (NO) and excess production of cytotoxic superoxide (O2-) and peroxynitrite (ONOO-) – the main components of oxidative stress. MORE»

REOPERATIVE CARDIAC SURGERY IN ADULT CONGENITAL HEART DISEASE PATIENTS
Mora
Bassem N. Mora, M.D., Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota, USA

Objectives: To discuss the spectrum of anomalies which require reoperative cardiac surgery in the adult congenital heart disease (ACHD) patient. Background: There are >1,000,000 ACHD patients in North America. Cardiac surgery in those is divided into cases involving great complexity MORE»

NOVEL BIOMARKERS OF LIPID AND LIPOPROTEIN METABOLISM
Mora
Samia Mora, M.D., Brigham and Women's Hospital, Boston, MA, USA

Objectives: Cardiovascular disease (CVD) can occur in individuals with low LDL-cholesterol (LDL-c). We investigated whether detailed measures of LDL subfractions and other lipoproteins can be used to assess CVD risk in a population with both low LDL-c and high C-reactive protein that was randomized to high-intensity statin or placebo. MORE»

THE ROLE OF MICRORNAS IN PERIPARTUM CARDIOMYOPATHY
Nair
Nandini Nair, M.D., Providence Sacred Heart Medical Center, Spokane, WA, USA

Peripartum cardiomyopathy (PPCM) causes considerable morbidity and mortality in young women during their reproductive years. The presentation is usually in the month preceding delivery up to 5 weeks post-partum. MORE»

REGULATION OF INTESTINAL GENES BY AN ORAL PEPTIDE REDUCES SYSTEMIC INFLAMMATION AND ATHEROGENESIS
Navab
Mohamad Navab, Ph.D., David Geffen School of Medicine, University of California, Los Angeles, CA, USA

A high fat, high cholesterol diet (Western diet, WD) increases the levels of the potent growth promoter unsaturated lysophosphatidic acid (LPA) in small intestine and plasma of LDLR-/- mice. Supplementing mouse chow with unsaturated LPA produced dyslipidemia and inflammation. WD increased the expression of the genes Acadl, Acot1 and Angptl4 while reducing that of Reg3g. MORE»


GENE-TARGETING OF NATRIURETIC PEPTIDE RECEPTOR-A ENHANCES THE EXPRESSION OF RAAS COMPONENTS LEADING TO INFLAMMATORY HYPERTENSIVE HEART DISEASE
Pandey
Kailesh N. Pandey, Ph.D., Tulane University Health Sciences Center, New Orleans, LA, USA

Atrial natriuretic peptide (ANP) was discovered over 30 years ago in the atrium of heart and has been extensively investigated with regard to physiology, pathophysiology, and cardiovascular disease therapeutics. MORE»

MISCONCEPTIONS AND DIAGNOSTIC CHALLENGES IN BIOPROSTHETIC VALVE THROMBOSIS
Pislaru
Sorin V. Pislaru, M.D., Ph.D., Mayo Clinic, Rochester, Minnesota, USA

Bioprosthetic valve thrombosis (BPVT) is a rare, but potentially life-threatening complication. In a review of the Mayo Clinic experience we found that BPVT was systematically under-reported on TTE, and that most cases occurred late post-implantation. MORE»

EXERCISE ECHOCARDIOGRAPHY: ADVANTAGES AND DISADVANTAGES
Prokudina
Maria Prokudina, M.D., Ph.D., Federal North-West Medical Research Center, St. Petersburg, Russia

The presentation will describe the advantages and disadvantages of exercise echocardiography (Ex Echo) for evaluation of coronary artery disease (CAD). Advantages and benefits of Ex Echo are the following: 1. Accuracy and availability; MORE»

TREATMENT OF OBSTRUCTIVE THROMBOSED PROSTHETIC HEART VALVE
Rahimtoola
Shabuddin H. Rahimtoola, M.D., University of Southern California, Los Angeles, CA, USA

A systematic review of the literature from 1996 -2012 revealed 9 studies with 48 patients with tricuspid OT PHV in whom thrombolytic therapy was successful in 88%. For left sided OT PHV, 17 studies comprising 756 patients had received thrombolytic therapy (TT) and in 13 studies comprising 662 patients had received surgical therapy (ST). MORE»

LIPID LOWERING IN PATIENTS WITH MILD AORTIC STENOSIS AND ELEVATED LOW DENSITY LIPOPROTEIN: THE SEAS STUDY
Rajamannan
Nalini M. Rajamannan, M.D., Mayo Clinic, Rochester, Minnesota, USA

Aims: To examine if pretreatment low density lipoprotein cholesterol (LDL) levels and aortic stenosis (AS) severity alter the efficacy of lipid-lowering therapy in AS patients. Methods and Results: Asymptomatic patients with AS randomized (1:1) to 40 mg Simvastatin + 10 mg Ezetimibe combination vs. placebo and =2 echocardiograms in the SEAS trial. MORE»

DIAGNOSTIC TRICKS AND TIMELY TREATMENT OF AORTIC INTRAMURAL HEMATOMA
Reddy
Hanumanth K. Reddy, M.D., St. Louis University Medical School, St. Louis, MO, USA

Aortic intramural hematoma is a variant of acute aortic syndrome with a presentation similar to that of acute aortic dissection but difficult to make a timely diagnosis. This entity may be easily missed because of the absence of the intimal flap often seen in classical dissection. MORE»

RELAXIN, A POTENTIAL THERAPY FOR ATRIAL FIBRILLATION
Salama
Guy Salama, Ph.D., University of Pittsburgh, Pittsburgh, PA, USA

Relaxin, a hormone of reproduction and has been identified as an insulin-like peptide with pleiotropic actions throughout the body including important cardiovascular actions. We recently demonstrated that Relaxin suppresses atrial fibrillation (AF) in spontaneously hypertensive rat (SHR) hearts by remodeling the extracellular matrix, modulating cardiac ion channels and reducing cell hypertrophy. MORE»

PRO-INFLAMMATORY AND ANTI-INFLAMMATORY MAST CELLS IN OBESITY AND DIABETES
Shi
Guo-Ping Shi, SC.D., D.SC., Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

Mast cells contribute to the pathogenesis of obesity and diabetes. Deficiency or pharmacological inactivation of mast cells protects mice from these metabolic diseases. This study demonstrates that leptin deficiency slants otherwise pro-inflammatory mast cells toward anti-inflammatory functions. MORE»


COMPUTED TOMOGRAPHY CORONARY ANGIOGRAPHY: DIAGNOSTIC AND PROGNOSTIC VALUE
Sozzi
Fabiola B. Sozzi, M.D., Ph.D., Cardiology Unit, Policlinico Hospital, Milan, Italy

Coronary multislice computed tomography (CT) is increasingly being used as a tool for non-invasive visualization of the coronary arteries (1). The technique provides information on atherosclerotic plaque burden and to some extent on plaque composition. The diagnostic value of coronary CT scan is high. MORE»

CHOLESTEROL GOALS & TARGETS: SHOULD WE IMPROVE IT?
Sperling
Laurence Sperling, M.D., Emory University School of Medicine, Atlanta, GA, USA

Appropriate intensity statins are recommended by the ACC/ AHA Blood Cholesterol Guidelines as first line lipid therapy for both high risk secondary prevention patients with established atherosclerotic cardiovascular disease (ASCVD) and post-acute coronary syndrome (ACS). MORE»

VIEWING HEART FAILURE AS INTERSTITIAL CANCER: DIAGNOSTIC AND THERAPEUTIC AVENUES
Spinale
Frank Spinale, M.D., Ph.D., University of South Carolina School of Medicine, Columbia, SC, USA

In contrast to public perception, the morbidity and mortality as well as the resultant health care costs associated with chronic heart failure (HF) are increasing and arguably reaching epidemic proportions, but improvements in diagnostic and therapeutic strategies for this disease have not been forthcoming. MORE»

GI PROTEIN AS POTENTIAL TARGET FOR THE TREATMENT OF HYPERTENSION
Srivastava
Madhu B. Anand-Srivastava, Ph.D., Faculty of Medicine, University of Montreal, Montreal, QC, Canada

Guanine nucleotide regulatory proteins (G proteins) play an important role in the regulation of a variety of physiological functions including blood pressure through the activation of different effectors. We have previously shown an overexpression of inhibitory G proteins (Gialpha proteins) in spontaneously hypertensive rats (SHR) and other models of hypertensive rats. MORE»

CARDIAC FIBROSIS IN HEART FAILURE
Taylor
Andrew J. Taylor, Ph.D., Alfred Hospital and Baker IDI Heart and Diabetes Institute, Melbourne, Australia

Myocardial fibrosis is a fundamental event in the development of cardiac failure, and is a common feature in all patients with advanced cardiac failure regardless of the aetiology of cardiomyopathy. Increasing myocardial fibrosis results in progressive deterioration of myocardial function, with more extensive myocardial fibrosis identified histologically in the hearts of patients with advanced heart failure. MORE»

 

STRATEGIES FOR PREVENTION OF CARDIOVASCULAR EVENTS IN PATIENTS WITH POLYVASCULAR DISEASE
Tomaru
Takanobu Tomaru, M.D., Toho University Sakura Hospital, Japan

Patients with severe carotid arterial sclerosis or those with polyvascular disease (PVD ) are at high risk for cardiovascular events. Ultra-sonography(US) is very useful for detection of PVD and we investigated usefulness of US and prognosis of patients with PVD or those with severe carotid arteriosclerosis. MORE»

UPDATE ON THE TREATMENT OF THE CHRONIC TOTAL OCCLUSION
Uretsky
Barry Uretsky, M.D., University of Arkansas for Medical Sciences, Little Rock, AR, USA

A key goal in treating obstructive coronary disease is complete revascularization (CR). Multiple observational and registry studies have suggested the value of CR in maximizing survival, minimizing long-term adverse cardiac events, and improving the quality of life. MORE»

 

 

SCREENING FOR CVD IN DIABETES: EVIDENCE AND RECOMMENDATIONS
Wong
Nathan D. Wong, Ph.D., University of California, Irvine, CA, USA

The ACC/AHA released evidence-based guidelines on cardiovascular disease (CVD) risk assessment, lifestyle, obesity, and cholesterol management. The risk assessment guideline recommended a new “Pooled Cohort Equations” calculator to estimate 10-year and lifetime risk of atherosclerotic CVD (ASCVD), and other measures-- premature family history of CVD, C-reactive protein, ankle brachial index, and coronary calcium scores to further stratify risk and inform the treatment decision. MORE»

ZHANG’S PHENOMENON (HIS ELECTROGRAM ALTERNANS) AND A NEW MODEL OF ATRIOVENTRICULAR NODE DUAL PATHWAY CONDUCTION
ZhangYouhua Zhang, M.D., Ph.D., New York Institute of Technology College of Osteopathic Medicine, NY, USA

Zhang’s phenomenon (originally His electrogram alternans), a new index of dual pathway atrioventricular (AV) node conduction, indicates that there are dual inputs rather than a final common pathway from the AV node into the His bundle. MORE»

 


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20th World Congress on Heart Disease

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